Artificial Intelligence (AI) and Machine Learning (ML) are transforming manufacturing processes, offering unprecedented opportunities to enhance sustainability and environmental stewardship. This comprehensive review analyzes the transformative impact of AI technologies on sustainable manufacturing, focusing on critical applications, including energy optimization, predictive maintenance, waste reduction, and circular economy implementation. Through systematic analysis of current research and industry practices, the study examines both the opportunities and challenges in deploying AI-driven solutions for sustainable manufacturing. The findings provide strategic insights for researchers, industry practitioners, and policymakers working towards intelligent and sustainable manufacturing systems while elucidating emerging trends and future directions in this rapidly evolving field.
The deubiquitinating enzyme cylindromatosis (CYLD) plays a fundamental role in regulating T cell development and activation. Previous studies have shown that CYLD is associated with autophagy, while AMP activated protein kinase (AMPK) pathway regulates the development of autophagy and affects cell metabolism. However, the mechanism by which CYLD affects autophagy and whether it affects the downstream metabolism of AMPKα remains unclear. In this study, we used the CYLD gene knockout model in Jurkat cells to investigate the mechanism of CYLD and autophagy and its relationship with cellular metabolism. The results show that CYLD deletion promotes autophagy through AMPKα/mTOR/ULK1 signaling pathway, promotes mitochondrial autophagy to improve mitochondrial function and attenuates cell lipid metabolism in Jurkat cells.
Fluvial floodplains are water-land transitional zones, playing an important role in hydrological and ecological systems. To date, the phosphorus migration and transformation in floodplain sediments remain elusive, which poses a large effect on river nutrient levels and primary productivity. This review summarized the sedimentary characteristics of floodplains and analyzed the spatial differences and temporal variations in phosphorus distribution. We further analyzed their potential change in floodplains under various conditions, determining the sedimentation and mineralization process of phosphorus. Meanwhile, phosphorus in the sediment will experience dynamic fluctuation as a source or sink of fluvial floodplains based on varying factors, including hydrological conditions, climate variations, biological activity, and pedological characteristics. In particular, the productivity and community population in floodplains, like vegetation and fishes, will be primarily associated with the periodic changes in phosphorus through food chain. Lastly, this review provided corresponding perspectives on improving the phosphorus administration in river floodplains based on existing problems. In total, it is anticipated that it will enhance the understanding of phosphorus resources or sink in the fluvial floodplains, contributing to the stability of aquatic ecosystems.
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial disease of unknown origin, characterized by radiological and histological features consistent with usual interstitial pneumonia (UIP). It is marked by a progressive worsening of dyspnea and a decline in lung function. Both IPF and PPF are comparable because they have poor prognoses with a median survival time from diagnosis of around 2–4 years without antifibrotic therapy. This review shows the main specific characteristics and differences of epidemiology, pathophysiology, clinical and radiological features, treatment, and prognosis of IPF and PPF.
The behaviour of co-axial rotors is well understood, and they are especially practical for large UAVs due to their increased thrust without changing the vehicle footprint. However, for co-axial systems with varying propeller diameters between the two disks, research is more limited. The goal of this paper was to determine an optimal configuration for several different unequal co-axial setups using numerous different propeller combinations and separation ratios. Propellers with diameters of 26 and 29 inches are tested at separation ratios of 0.05 to 0.35. Thrust and power were collected using an off-the-shelf FS15-TYTO thrust stand, with the upstream and downstream propellers running at equal throttles. From this, performance was assessed through efficiency, thrust, and power consumption, and comparisons were made to an ideal combination without losses. The results show that for unequal combinations, the user should place the smaller propeller upstream for greater efficiency, but for maximum thrust capacity, two equal propellers are preferred. When compared to two independent rotors of the same size, a 26″ upstream rotor and a 29″ downstream rotor minimised thrust loss to 16%, compared to 23% for the opposite arrangement. It was also found that the optimal separation ratio is always approximately 0.2.
