Photocatalytic degradation of antibiotic molecules has great significance in environmental pollution control. Bi4Ti3O12 with a layered structure is one of the emerging visible−light−responsive photocatalysts. However, the environmental effects of antibiotic degradation have not received sufficient attention. This study employed plate−like Bi4Ti3O12 derived from Na2Ti3O7 nanowires for ciprofloxacin (CIP) degradation, and investigated the biotoxicity of degradation products on aquatic organisms and plant seedlings. It was found that an appropriate hydrothermal treatment time with ethylene glycol could slightly enhance the photocatalytic performance of Bi4Ti3O12, and this might be attributed to the increased density of active sites resulting from the regulation of microstructure. Concurrently, the degradation products of CIP were detected and predicted for biotoxicity; the effects of the CIP degradation residual solution on the growth of peas, wheat, and zebrafish larvae were also investigated. Under the present experimental conditions, the Bi4Ti3O12−24h photocatalyst−involved CIP degradation process could reduce the biotoxicity of the CIP solution (40 mg/L) and exhibit low toxicity to several individual organisms, including some actual plants and animals.
Culinary nutrition education (CNE) involves structured, experiential learning that combines cooking skills with nutrition knowledge. While traditionally evaluated for physical health and dietary outcomes, emerging evidence suggests that CNE may also confer psychosocial benefits, such as improvements in self-efficacy, social connectedness, mood, and quality of life. This perspective (1) discusses the latest evidence for the psychosocial impact of CNE across developmental stages, (2) articulates plausible psychosocial mechanisms, (3) highlights limitations in current research, and (4) proposes directions for future research, intervention design, and implementation. Overall, evidence points to potential psychosocial benefits across the lifespan, although current research quality is variable. This perspective suggests that CNE, as an experiential learning approach, may support mental health by fostering self-efficacy building, promoting autonomous decision-making, enhancing social connection, and contributing to social identity formation across the lifespan. Integrating CNE into schools, communities, and other settings has the potential to deliver scalable, equitable psychosocial benefits. Future research should further examine effects over time, dose-response relationships, and the underlying psychosocial mechanisms. CNE interventions should be evidence-based, systematically co-designed with consumers, and tailored to participants’ developmental stage and needs to maximise their psychosocial benefits.
This study examines how classical Islamic legal concepts are rearticulated within contemporary Indonesian halal-health governance. Focusing on the concepts of ʿurf (custom) and istiṣlāḥ (public interest), the research investigates how normative traditions are integrated into biomedical regulation and institutional decision-making. Using qualitative textual and discursive analysis, the study analyzes fatwa documents, regulatory guidelines, policy statements, and scholarly writings related to halal pharmaceuticals, vaccination, and health certification. The findings indicate that ʿurf is increasingly mediated through administrative and certification frameworks, while istiṣlāḥ is progressively proceduralized through technical evaluation and performance indicators. Religious authority is reconfigured through interdisciplinary expert networks that combine juristic reasoning with scientific and bureaucratic validation. At the discursive level, Islamic ethical vocabulary is systematically integrated with public health rationality, producing hybrid forms of moral-technical legitimacy. These transformations suggest that halal-health governance operates through negotiated continuity rather than epistemic rupture. Classical legal concepts are neither abandoned nor preserved unchanged; rather, they function as discursive interfaces between tradition and institutional governance. By highlighting the infrastructural conditions of ethical adaptation, this study contributes to a more nuanced understanding of Islamic normativity under contemporary biocultural and regulatory regimes.
Uncertainty and calibration are major challenges in hydrologic and hydraulic analysis, especially in watershed applications involving groundwater flow and contaminant transport. This study presents an integrated modeling framework for comprehensive simulation of groundwater flow and contaminant transport, with automated calibration and sensitivity analysis capabilities. The framework extends traditional Fortran-based modeling by incorporating the statistical, numerical, and visualization strengths of the R environment. In the proposed approach, the Fortran code is executed within R, while the Fortran program employs a finite-volume time-splitting method to discretize the governing equations of groundwater flow and contaminant transport. Integration with R statistical packages improves model calibration, sensitivity evaluation, and visualization of groundwater contamination results. To illustrate the applicability of the framework, two test cases of groundwater flow and contaminant transport through porous media were conducted. Results demonstrate the accuracy, efficiency, and enhanced visualization capabilities of the integrated system. Ultimately, the framework is intended to support three-dimensional analysis of pollution plume evolution in heterogeneous media and to investigate interactions among multiple contaminant sources in watershed systems.
Systemic Sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis in connective tissues. Fibroblasts are the effector cells of fibrosis since they contribute to the production of collagen and other extracellular matrix components. The goal of this study is to compare the transcriptomic profiles of primary human SSc skin and SSc lung fibroblasts. First, we conducted a meta-analysis of differentially expressed (DE) genes from two previously published differential analyses (SSc vs. normal) using skin and lung fibroblasts, observing 8.7% overlap in DE genes and 30% overlap in impacted pathways. Next, we characterized the signature of several genes of interest from the pro- and anti-fibrotic programs within the unique and overlap groups and explored overlapping drugs that are predicted to revert DE genes to “normal expression”. Finally, we identified 3760 DE genes between SSc lung and SSc skin fibroblasts, highlighting that fibroblasts in the disease state carry a tissue-specific signature that should be taken into consideration for therapeutic development. We also identified core genes that can serve as common targets for both skin and lung in SSc. To our knowledge, this is the first study to describe overlapping genes and pathways in primary human skin and lung fibroblasts from SSc patients.
