Fibrosis

Open Access  ISSN: 2959-605X (Online);  2959-6041 (Print)

Fibrosis aims to provide a unique forum through which the Fibrosis community will learn about the latest, most significant Fibrosis-related advances across the life, physical, applied and social sciences. Areas of interest include fundamental, preclinical research that furthers our understanding of the mechanisms underlying scar initiation, propagation and progression; work aiming to translate this knowledge to the clinic by focusing on new approaches for the development and delivery of diagnostic and therapeutic modalities; clinical studies informing Fibrosis diagnosis, treatment and prevention; and new ways of understanding the global societal impact of Fibrosis.

Editor-in-Chief

Guoying  Yu Prof. Dr. Guoying Yu
State Key Laboratory of Cell Differentiation and Regulation, College of Life Sciences, Henan Normal University, Xinxiang, China
Ralf  Weiskirchen Prof. Ralf Weiskirchen
Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, 52074, Germany

Editorial Board

Meeting Report Open Access
The Cellular and Metabolic Bases of Organ Fibrosis: UNIA Workshop 2023 in Baeza, Spain
  • Fibrosis 2024, 2(1), 10001; https://doi.org/10.35534/fibrosis.2024.10001
  • Santiago Lamas   Katalin Susztak   Fernando Rodríguez-Pascual   Check
     20 Feb 2024

    Fibrosis is defined by scarring and tissue hardening caused by excess deposition of extracellular matrix components, mainly collagens. A fibrotic resp...

    Review Open Access
    TANGO1 Dances to Export of Procollagen from the Endoplasmic Reticulum
  • Fibrosis 2023, 1(2), 10008; https://doi.org/10.35534/fibrosis.2023.10008
  • Carol M. Artlett   Lianne M. Connolly   Check
     21 Dec 2023

    ABSTRACT: The endoplasmic reticulum (ER) to Golgi secretory pathway is an elegantly complex process whereby protein cargoes are manufactured, folded, ...

    Article Open Access
    Translational Studies Reveal the Divergent Effects of Simtuzumab Targeting LOXL2 in Idiopathic Pulmonary Fibrosis
  • Fibrosis 2023, 1(2), 10007; https://doi.org/10.35534/fibrosis.2023.10007
  • Milena S. Espindola   David M. Habiel   Ana Lucia Coelho   Tanyalak Parimon    Peter Chen    Amanda Mikels-Vigdal   Cory M. Hogaboam   Check
     28 Nov 2023

    The composition of extracellular matrix (ECM) is altered during pathologic scarring in damaged organs including the lung. One major change in the ECM ...

    Article Open Access
    The Severity of Isoproterenol-induced Myocardial Fibrosis and Related Dysfunction in Mice is Strain-dependent
  • Fibrosis 2023, 1(2), 10006; https://doi.org/10.35534/fibrosis.2023.10006
  • Chao Wang   Amlan Chakraborty   Deidree V. N. Somanader   Michael Nguyen   Chen Wei   Robert E. Widdop   Chrishan S. Samuel   Check
     17 Oct 2023

    The isoproterenol (or isoprenaline; ISO)-induced model of myocardial injury provides a non-surgical means of establishing features of dilated cardiomy...

    Article Open Access
    Hepatic Lysosomal Enzyme Activity in Primary Biliary Cholangitis
  • Fibrosis 2023, 1(1), 10005; https://doi.org/10.35534/fibrosis.2023.10005
  • Ioannis Tsomidis   Georgios Notas   Argyro Voumvouraki   Dimitrios Samonakis   Mairi Koulentaki   Elias Kouroumalis   Check
     16 Sep 2023

    Background: Lysosomal enzymes are implicated in autophagy and senescence. Hepatic lysosomal enzymes have not been studied in Primary Biliary Cholangit...

    Article Open Access
    Comprehensive Landscape of Matrix Metalloproteinases in the Pathogenesis of Idiopathic Pulmonary Fibrosis
  • Fibrosis 2023, 1(1), 10004; https://doi.org/10.35534/fibrosis.2023.10004
  • Zhongzheng Li   Huabin Zhao   Shenghui Wang   Peishuo Yan   Hongmei Yuan   Mengxia Zhao   Ruyan Wan   Jiawei Wang   Zhao Zhu   Zhenwei Li   Juntang Yang   Yajun Li   Lan Wang   Check
     19 May 2023

    Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic interstitial lung disease with unknown etiology. Matrix metalloproteinases (MMPs) are in...

    Communication Open Access
    Established Hepatic Stellate Cell Lines in Hepatology Research
  • Fibrosis 2023, 1(1), 10003; https://doi.org/10.35534/fibrosis.2023.10003
  • Ralf Weiskirchen   Check
     21 Mar 2023

    Hepatic stellate cells comprise a minor cell population in the liver that plays a key role in the pathogenesis of hepatic fibrosis. In chronic liver d...

    Perspective Open Access
    Pulsed Ultraviolet C as a Potential Treatment for COVID-19
  • Fibrosis 2023, 1(1), 10002; https://doi.org/10.35534/fibrosis.2023.10002
  • Elroei David   Alina Karabchevsky   Marina Wolfson   Vadim E. Fraifeld   Check
     07 Mar 2023

    Currently, low dose radiotherapy (LDRT) is being tested for treating life-threatening pneumonia in COVID-19 patients. Despite the debates over the c...

    Communication Open Access
    Established Hepatic Stellate Cell Lines in Hepatology Research
  • Fibrosis 2023, 1(1), 10003; https://doi.org/10.35534/fibrosis.2023.10003
  • Ralf Weiskirchen   Check
     21 Mar 2023

    Hepatic stellate cells comprise a minor cell population in the liver that plays a key role in the pathogenesis of hepatic fibrosis. In chronic liver d...

    Perspective Open Access
    Pulsed Ultraviolet C as a Potential Treatment for COVID-19
  • Fibrosis 2023, 1(1), 10002; https://doi.org/10.35534/fibrosis.2023.10002
  • Elroei David   Alina Karabchevsky   Marina Wolfson   Vadim E. Fraifeld   Check
     07 Mar 2023

    Currently, low dose radiotherapy (LDRT) is being tested for treating life-threatening pneumonia in COVID-19 patients. Despite the debates over the c...

    Article Open Access
    Comprehensive Landscape of Matrix Metalloproteinases in the Pathogenesis of Idiopathic Pulmonary Fibrosis
  • Fibrosis 2023, 1(1), 10004; https://doi.org/10.35534/fibrosis.2023.10004
  • Zhongzheng Li   Huabin Zhao   Shenghui Wang   Peishuo Yan   Hongmei Yuan   Mengxia Zhao   Ruyan Wan   Jiawei Wang   Zhao Zhu   Zhenwei Li   Juntang Yang   Yajun Li   Lan Wang   Check
     19 May 2023

    Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic interstitial lung disease with unknown etiology. Matrix metalloproteinases (MMPs) are in...

    Article Open Access
    The Severity of Isoproterenol-induced Myocardial Fibrosis and Related Dysfunction in Mice is Strain-dependent
  • Fibrosis 2023, 1(2), 10006; https://doi.org/10.35534/fibrosis.2023.10006
  • Chao Wang   Amlan Chakraborty   Deidree V. N. Somanader   Michael Nguyen   Chen Wei   Robert E. Widdop   Chrishan S. Samuel   Check
     17 Oct 2023

    The isoproterenol (or isoprenaline; ISO)-induced model of myocardial injury provides a non-surgical means of establishing features of dilated cardiomy...

    Article Open Access
    Hepatic Lysosomal Enzyme Activity in Primary Biliary Cholangitis
  • Fibrosis 2023, 1(1), 10005; https://doi.org/10.35534/fibrosis.2023.10005
  • Ioannis Tsomidis   Georgios Notas   Argyro Voumvouraki   Dimitrios Samonakis   Mairi Koulentaki   Elias Kouroumalis   Check
     16 Sep 2023

    Background: Lysosomal enzymes are implicated in autophagy and senescence. Hepatic lysosomal enzymes have not been studied in Primary Biliary Cholangit...

    Article Open Access
    Translational Studies Reveal the Divergent Effects of Simtuzumab Targeting LOXL2 in Idiopathic Pulmonary Fibrosis
  • Fibrosis 2023, 1(2), 10007; https://doi.org/10.35534/fibrosis.2023.10007
  • Milena S. Espindola   David M. Habiel   Ana Lucia Coelho   Tanyalak Parimon    Peter Chen    Amanda Mikels-Vigdal   Cory M. Hogaboam   Check
     28 Nov 2023

    The composition of extracellular matrix (ECM) is altered during pathologic scarring in damaged organs including the lung. One major change in the ECM ...

    Review Open Access
    TANGO1 Dances to Export of Procollagen from the Endoplasmic Reticulum
  • Fibrosis 2023, 1(2), 10008; https://doi.org/10.35534/fibrosis.2023.10008
  • Carol M. Artlett   Lianne M. Connolly   Check
     21 Dec 2023

    ABSTRACT: The endoplasmic reticulum (ER) to Golgi secretory pathway is an elegantly complex process whereby protein cargoes are manufactured, folded, ...

    Meeting Report Open Access
    The Cellular and Metabolic Bases of Organ Fibrosis: UNIA Workshop 2023 in Baeza, Spain
  • Fibrosis 2024, 2(1), 10001; https://doi.org/10.35534/fibrosis.2024.10001
  • Santiago Lamas   Katalin Susztak   Fernando Rodríguez-Pascual   Check
     20 Feb 2024

    Fibrosis is defined by scarring and tissue hardening caused by excess deposition of extracellular matrix components, mainly collagens. A fibrotic resp...