Arrestin beta 1 Regulates Alveolar Progenitor Renewal and Lung Fibrosis

The molecular mechanisms that regulate progressive pulmonary fibrosis remain poorly understood. Type 2 alveolar epithelial cells (AEC2s) function as adult stem cells in the lung. We previously showed that there is a loss of AEC2s and a failure of AEC2 renewal in the lungs of idiopathic pulmonary fibrosis (IPF) patients. We also reported that beta-arrestins are the key regulators of fibroblast invasion, and beta-arrestin 1 and 2 deficient mice exhibit decreased mortality, decreased matrix deposition, and increased lung function in bleomycin-induced lung fibrosis. However, the role of beta-arrestins in AEC2 regeneration is unclear. In this study, we investigated the role and mechanism of Arrestin beta 1 (ARRB1) in AEC2 renewal and in lung fibrosis. We used conventional deletion as well as cell type-specific deletion of ARRB1 in mice and found that Arrb1 deficiency in fibroblasts protects mice from lung fibrosis, and the knockout mice exhibit enhanced AEC2 regeneration in vivo, suggesting a role of fibroblast-derived ARRB1 in AEC2 renewal. We further found that Arrb1-deficient fibroblasts promotes AEC2 renewal in 3D organoid assays. Mechanistically, we found that CCL7 is among the top downregulated cytokines in Arrb1 deficient fibroblasts and CCL7 inhibits AEC2 regeneration in 3D organoid experiments. Therefore, fibroblast ARRB1 mediates AEC2 renewal, possibly by releasing chemokine CCL7, leading to fibrosis in the lung.

Exact and Heuristic Approaches to Surveillance Routing with a Minimum Number of Drones

The rising cost and scarcity of human labor pose challenges in security patrolling tasks, such as facility security. Drones offer a promising solution to replace human patrols. This paper proposes two methods for finding the minimum number of drones required for efficient surveillance routing: an ILP-based method and a greedy method. We evaluate these methods through experiments, comparing the minimum number of required drones and algorithm runtime. The findings indicate that the ILP-based method consistently yields the same or a lower number of drones needed for surveillance compared to the greedy method, with a 73.3% success rate in achieving better results. However, the greedy method consistently finishes within one second, whereas the ILP-based method sometimes significantly increases when dealing with 14 more locations. As a case study, we apply the greedy method to identify the minimum drone surveillance route for the Osaka-Ibaraki Campus of Ritsumeikan University.

Monitoring Complexity in Clean Energy Systems Applications

Clean energy applications often involve systems with technological process monitoring. This supervision aims to optimize operation, in particular efficiency, performance and compatibility with dedicated criteria. Most of these energy systems involve complex procedures. A complex procedure is an arrangement of compound processes interacting in interdependent behaviors. The supervision of these complex procedures focuses on the interaction of compound processes, their digital coupling and the handling of uncertainties in their detection and digital tools. Real-virtual pairs, such as digital twins, could carry out such surveillance. This commentary aims to analyze and illustrate such supervision in clean electromagnetic energy systems based on a review of the literature. The notion of complexity and the interactions of the compound processes involved are first addressed and detailed. The modeling of these interactions is presented through the mathematical coupling of the electromagnetic equations with other equations of the phenomena involved. These phenomena are linked to the functional or environmental behaviors of the systems. Compound process monitoring in complex procedures is then analyzed taking into account threats, unsolicited external events and uncertainties related to the sensing and digital tools involved. This contribution illustrated several points relating to, the relationship between the complexities of a real energy procedure and its coupled virtual model, the dependence of the model reduction strategy on each specific application and the reduction of uncertainties through the matching of real-virtual pairs. The different analyses are supported by literature references permitting more information when necessary.

Hydroecology and Engineering Editorial

Visible Light-Driven H₂O₂ Photoelectrocatalytic Synthesis Over a Tandem Electrode Strategy

Photocatalytic synthesis of hydrogen peroxide (H₂O₂) can be an environmentally friendly and energy-saving solution. However, the oxygen reduction reaction (ORR) rate is limited due to the low solubility of O₂ in water. In this study, a modified BiVO₄ (BVO) photoanode combined with an Sn-coordinated phthalocyanine gas diffusion electrode (SnPc-GDE) was employed for the synthesis of H₂O₂, and the oxy-gen reduction reaction rate was increased through a unique three-phase interface system. When visible light was irradiated on the BVO photoanode, the hole-electron pairs were excited and the oxygen evolution reaction (OER) was driven through the holes, and the excited electrons were transferred to the SnPc-GDE to reduce O₂ for the synthesis of H₂O₂. Oxygen vacancy enrichment on the BVO electrode was achieved by photoetching and annealing under an N₂ atmosphere, which effectively improved the carrier separation efficiency. Complexation with a WO₃ layer formed a built-in electric field, which further promoted the electron-hole pair separation. The SnPc catalyst-modified GDE electrode has the best selectivity for ORR and remains stable during long-term reactions. Under bias-free conditions, the generation rate of H₂O₂ reached 952.5 μM·L⁻¹·h⁻¹, with a Faradaic efficiency of 48.4%. This study provided a practical strategy for designing a highly efficient BVO/SnPc-GDE photoelectrochemical system to produce H₂O₂ based on improvement in electron-hole transmission efficiency and product selectivity.

Paleo-Asian Cultural Phenomena of Ancient Beringia: Population Convergence and Solution of Ethnic Self-Identification

Authors offer for a discussion the materials from studies of archaic culture elements that include body modifications in ethnic groups in the context of population genetic data from native peoples of the Far North. The authors consider materials from the territory of ancient Beringia which include a part of Chukotka and Kamchatka in Russia, Alaska in the USA and several island groups in between. The working hypothesis of the study involves the identification of common and specific features of body modifications in ethnic groups having similar population genesis. This allows to clarify the specifics of the regional contacts. Body modifications (tattoos, piercings, etc.) are considered as a way of a person’s self-identification and a form of his group membership (in this case—ethnic group). The study used ethnographic, archaeological, paleo-history, folklore materials and up-to-date data that include genetic research of contemporary ethnic groups inhabiting the territory of ancient Beringia and maintaining their traditional way of life. The methodology base of the research is based on formalized approach and cross-cultural analysis evidence of the similarity/difference of the population in combination with the method of comparative analysis of DNA data and information about their genetic structure.

Construction of a Comprehensive International Legal Protection Mechanism for Climate Refugees

Climate refugee has become an unavoidable major right crisis challenge for the international community. However, the corresponding development of positive international law is obviously imperfect. The basic rights of climate refugees cannot be fully guaranteed by international law. They are always facing problems such as unclear legal status lack of protection of basic rights, and imperfect relief mechanism. Those vulnerable groups who lack resources and migration abilities suffer more serious rights violations because they are forced to stay in place. Compared with the risk-management framework and right-protection framework, the comprehensive international legal protection mechanism is the inevitable choice for climate refugees’ rights relief in the post-2012 period. The rights of climate refugees set out in the preamble of the Paris Agreement in 2015, the New York Declaration on Refugees and Migrants in 2016, the Global Refugee Compact in 2018, and the Global Compact for Security, Order and Regular Migration formally incorporated the issues of refugees and migrants caused by climate change, laying the foundation for this choice. However, it is a long and difficult way to build a perfect comprehensive international response to climate change. It is not only necessary to realize the integration of human rights law and climate law at the conceptual level, but also to integrate the different perspectives of the two laws and build a set of scientific and reasonable cooperation mechanism.

Can Digital Village Construction Reduce Rural Income Disparity?—Empirical Analysis Based on Inter-provincial Panel Data in China

Cutting the income disparity within rural areas is one of the key priorities in seeking common prosperity in China. Based on the panel data of 20 provinces in China from 2011 to 2020, we empirically analyze the impact of digital village construction on rural income disparity by building a digital village construction level indicator system which represents three dimensions of digitalization in rural areas, i.e., digitalization of rural infrastructure, digitalization of agricultural development and digitalization of rural residents’ life. Overall, the level of digital village construction in rural China has shown a development trend of gradual improvement, while the development level in various regions is unbalanced and varies greatly. The results of the fixed-effect model show that, digital village construction can significantly reduce the income disparity in rural areas, whereas the effect is significant in eastern China, insignificant in central and western China. It is recommended to increase the investment in funds and talents and take full consideration and advantage of local conditions, while promoting the development of new rural digital economy, so to achieve the development goal of common prosperity of rural residents.

Australopithecine Taxonomy and Phylogeny and the Savanna Hypothesis; Comment on Vaneechoutte et al. Have We Been Barking up the Wrong Ancestral Tree? Australopithecines Are Probably Not Our Ancestors. Nat. Anthropol. 2023, 2, 10007

Biodegradable Composite Materials based on Cassava Starch and Reinforced with Topinambur (Helianthus tuberosus) Aerial Part Fiber

The cultivation of topinambur (Helianthus tuberosus) has aroused the interest of producers since it is a source of inulin and can be used for biofuel production. During tuber processing, the aerial part of the crop remains as a by-product with no practical application. This work aimed to characterize the fibers obtained from the aerial part of topinambur and to evaluate their reinforcing potential in cassava starch-based films. Starch-based films with topinambur fiber (0, 5, and 10%) were prepared by extrusion followed by thermocompression. Topinambur residue contains 88.6% of total fiber, 8.5% ash, and 0.68% lipid. Mechanical film properties evidenced the reinforcement action of topinambur fiber, 10% content was able to increase up to 70% the Young’s modulus. SEM micrographs evidenced the good fiber-matrix interaction. UV-visible capacity, opacity, and chromaticity parameters of TPS films increased with fiber content in the formulation. Fiber incorporation improved the hydrophobicity of the biocomposite materials by increasing the contact angle. Starch-based films biodegraded more than 55% after 110 days, showing a similar trend to that of microcrystalline cellulose. Thus, topinambur residue can be effectively used as a reinforcing agent for TPS materials, being an innovative and non-toxic additive within the circular economy premises.