Fibrosis, Volume 1, Issue 1 (September 2023) – 5 articles

Cover Story (view full-size image):
Classification of hepatic stellate cell (HSC) lines. Spontaneously or artificially immortalized HSC lines derived from mouse (yellow), rat (orange) and human (red) can be used in place of primary HSC in biomedical research. Most of them represent a transdifferentiated, highly proliferative, extracellular matrix-producing myofibroblastic phenotype. Some lines can be partly reverted by treatment with retinol, fatty acids, or the latency-associated peptide of TGF-β1 into a quiescent, vitamin A-storing phenotype. However, compared to primary cells, these infinite growing lines do not always accurately replicate the biology of primary HSC and can therefore not fully replace primary cells in hepatology research.
Perspective Open Access
Pulsed Ultraviolet C as a Potential Treatment for COVID-19
  • Fibrosis 2023, 1(1), 10002;
  • Elroei David   Alina Karabchevsky   Marina Wolfson   Vadim E. Fraifeld   Check
     07 Mar 2023

    Currently, low dose radiotherapy (LDRT) is being tested for treating life-threatening pneumonia in COVID-19 patients. Despite the debates over the c...

    Communication Open Access
    Established Hepatic Stellate Cell Lines in Hepatology Research
  • Fibrosis 2023, 1(1), 10003;
  • Ralf Weiskirchen   Check
     21 Mar 2023

    Hepatic stellate cells comprise a minor cell population in the liver that plays a key role in the pathogenesis of hepatic fibrosis. In chronic liver d...

    Article Open Access
    Comprehensive Landscape of Matrix Metalloproteinases in the Pathogenesis of Idiopathic Pulmonary Fibrosis
  • Fibrosis 2023, 1(1), 10004;
  • Zhongzheng Li   Huabin Zhao   Shenghui Wang   Peishuo Yan   Hongmei Yuan   Mengxia Zhao   Ruyan Wan   Jiawei Wang   Zhao Zhu   Zhenwei Li   Juntang Yang   Yajun Li   Lan Wang   Check
     19 May 2023

    Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic interstitial lung disease with unknown etiology. Matrix metalloproteinases (MMPs) are in...

    Article Open Access
    Hepatic Lysosomal Enzyme Activity in Primary Biliary Cholangitis
  • Fibrosis 2023, 1(1), 10005;
  • Ioannis Tsomidis   Georgios Notas   Argyro Voumvouraki   Dimitrios Samonakis   Mairi Koulentaki   Elias Kouroumalis   Check
     16 Sep 2023

    Background: Lysosomal enzymes are implicated in autophagy and senescence. Hepatic lysosomal enzymes have not been studied in Primary Biliary Cholangit...