Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma characterized by monoclonal immunoglobulin M (IgM) overproduction, leading to hyperviscosity syndrome and microvascular complications. While increased plasma viscosity is a well-recognized feature of WM, the impact of extreme IgM elevation on intrinsic red blood cell (RBC) mechanical properties remain incompletely characterized. Here, we report a case of WM with markedly elevated IgM associated with profound impairment of RBC deformability. Therapeutic plasma exchange rapidly reduced serum IgM levels, accompanied by parallel and sustained improvement in RBC deformability. Given the importance of RBC deformability in microvascular blood flow, these findings highlight a reversible, IgM-mediated alteration in RBC mechanics and provide novel insights into microcirculatory dysfunction in WM.
To address the environmental challenges posed by massive phosphogypsum (PG) stockpiles and groundwater fluoride contamination, this study developed an eco-friendly strategy for synthesizing lanthanum-doped hydroxyapatite (La-PGHAP) from PG waste via an acid precipitation-hydrothermal method. The synthesized La-PGHAP exhibited a spherical morphology, high crystallinity, and a significantly enhanced specific surface area of 53.11 m2/g. Batch adsorption experiments revealed that pH critically influenced fluoride (F−) removal, with maximum adsorption capacities of 8.20 mg/g (PGHAP) and 31.98 mg/g (La-PGHAP) at pH 4. The adsorption process followed pseudo-second-order kinetics and the Langmuir isotherm model, indicating chemisorption-dominated monolayer adsorption. La doping introduced Lewis acid-base interactions through La3+–F− coordination, improving both adsorption capacity and stability across a wide pH range (2–10). Reusability tests demonstrated that La-PGHAP retained 85.4% of its initial capacity after 4 cycles. This “waste-to-waste” approach not only repurposes PG into a high-efficiency adsorbent but also provides a sustainable solution for mitigating fluoride pollution, showcasing significant potential for industrial-scale water treatment applications.
Rights of Nature (RoN) represent an innovative form of environmental governance. However, the diverse application of RoN across varying socio-ecological contexts remains under-researched. This paper employs the “Roots of Rights” (RoR) approach for a comparative analysis. We examine RoN’s institutionalisation, implementation, and contestation in Germany and Aotearoa New Zealand, focusing on underlying relational values. Our analytical framework investigates two core dimensions: political dynamics of marginalisation and the role of relational approaches in the codification process. The findings reveal a fundamental divergence in RoN’s function. In Germany, RoN operates primarily as a radical theoretical tool. It is used by civil society to challenge the prevailing anthropocentric legal tradition. Conversely, legal personhood in New Zealand (e.g., Whanganui River) is a direct political product of Treaty Settlements. These frameworks serve the political self-determination and emancipation of Māori Iwi. Crucially, they codify a deeply-rooted, pre-existing relational worldview (tikanga). We conclude that RoN functions as a “thin” conceptual instrument in Germany, but as a ‘”hick”, politically instrumental means of securing non-hegemonic norms in New Zealand.
Climate change has become a critical global concern due to its adverse impacts on both humans and the environment. In alignment with Sustainable Development Goal 13, which calls for urgent action to combat climate change and its effects, this study examines community perceptions of climate change in Ghana, using evidence from Dakodwom in the Ashanti Region. The study specifically aims to: (1) examine the association between perceived climate change and the perceptions of its causes within the Dakodwom community, (2) assess the association between perceived climate change, its indicators, and trends, (3) examine the determinants of perceived climate change, and (4) identify practices that could mitigate climate change–related challenges. A structured questionnaire comprising closed-ended questions was used to collect data. Pearson’s chi-square test was employed to determine the relationship between perceived climate change and its perceived causes, as well as to assess the significance of respondents’ perceptions of various climate indicators and trends. Binary logistic regression was further applied to identify the factors influencing perceived climate change. The findings reveal that respondents attribute perceived climate change primarily to burning, deforestation, vehicle emissions, industrial emissions, agricultural activities, and urbanization. Participants demonstrated statistically significant awareness of changes in rainfall patterns, temperature increases, wind activity, and extreme weather events, indicating noticeable environmental changes. The regression results show that employment status and awareness of activities such as burning, agricultural activities, and industrial emissions are the significant determinants of perceived climate change. Additionally, the study identifies recycling, composting, community education, and the adoption of innovative waste-management technologies as practical strategies with potential to mitigate climate change–related challenges. Based on these findings, local authorities and environmental agencies should prioritize investments in improved waste-management systems, community composting facilities, and green infrastructure initiatives, including tree planting and environmentally sustainable agricultural practices, to address the observed increases in temperature, wind activity, and extreme weather events.
The global urbanization process is currently taking diverse territorial forms, leading to increased consumption of rural space through the creation of eco-cities. Within this context of transformation and the shifting nature of urban spaces, concepts and ideological frameworks are emerging to address environmental degradation caused by population concentration. Ecological Civilization (eco-civ) originated in China as a broad framework for managing new territorial processes through the construction of new eco-cities or the development of a comprehensive rural revitalization program that strengthens the urban-rural relationship. The major questions arising from this new process of rural revitalization in Chinese territories—and from the very concept of ecological civilization—can be summarized as follows: a simplification of the countryside, a loss of rural identity, the emergence of a post-agrarian society, the urbanization of rural areas, and an exacerbation of urban dependence on rural areas. Consequently, alternative approaches are proposed, based on multiple place-based approaches and actions that develop and adapt the fundamental principles of environmental and spatial renewal to each specific territory.
