Fibrosis of vital organs such as the lungs, liver, and kidneys is a serious condition without effective causal treatment. Here, we suggest the use of the sphingolipid sulfatide and its isoform C16, which we have found to inhibit the growth of fibroblasts. In the lungs, sulfatide can be easily administered via an inhalation spray. Alternatively, fenofibrate, an anti-cholesterol drug with no major side effects, may be used, as it enhances the body’s own production of sulfatide.
Traditional indices such as dp/dt max remain widely used in assessing ventricular contractility, yet their load-dependence limits clinical precision, particularly during dynamic hemodynamic shifts. This letter to the Editor advocates for a more physiologically grounded approach using dual pressure catheters equipped with two high-fidelity sensors, one in the left ventricle (LV) and one in the aorta, to capture real-time pressure gradients and valve events with high temporal resolution. When combined with transient inferior vena cava occlusion (IVCO), this setup enables accurate identification of the true end-systolic (ES) point, typically marked by dp/dt min or the dicrotic notch on the aortic pressure waveform. This method allows for the construction of more physiologically valid end-systolic pressure-volume relationships (ESPVR). It introduces the novel peak pressure end-systolic pressure-volume relationship (PPESPVR) model, which links peak LV pressure to the ES point within a single cardiac cycle. The resulting volume intercept (Vint) and end-systolic fraction (ESF) offer new insights into myocardial performance under varying preload and afterload conditions, without requiring extensive hemodynamic manipulation. This dual-sensor approach not only enhances diagnostic accuracy but also opens the door to real-time, patient-specific contractility assessment in both research and clinical settings.
Veterinary forensic pathology is an interdisciplinary field that critically investigates animal mortality under suspicious or unlawful circumstances. Among various causes of death, drowning remains one of the most diagnostically challenging conditions due to its pathophysiological complexity and the lack of pathognomonic post-mortem findings. Drowning in animals typically results from submersion or immersion in liquid, leading to asphyxial death with distinct physiological consequences depending on the medium, either freshwater or saltwater. The post-mortem diagnosis of drowning is complicated by factors such as environmental contamination, autolysis, and the difficulty in distinguishing ante-mortem from post-mortem immersion. While classical diagnostic indicators, such as pulmonary oedema and frothy exudate, are frequently non-specific, the diatom test remains widely utilised in forensic investigation. However, environmental confounders and inconsistent protocols limit the technique’s reliability. This review critically evaluates current diagnostic methodologies for drowning in animals, including macroscopic, microscopic, and ancillary techniques, with particular attention to the diatom test and emerging technologies. It proposes an integrated diagnostic approach to enhance diagnostic accuracy and support judicial and animal welfare outcomes.
Four main types of faults can occur at the DC side of any Photovoltaic System (PVS). These faults are quite dangerous and can cause permanent damage to the photovoltaic modules if not addressed promptly. The faults include open circuit, short circuit, degradation, and partial shading. Short circuit faults are classified into line-to-line (L-L) and line-to-ground (L-G). Detecting these faults requires specialized algorithms. This paper tackles this complex issue through (1) fault-finding equations and the placement of current sensors, and (2) a new hybrid algorithm based on data from the fault-finding equations and current sensors. Numerous simulations using PSIM 2021 were conducted to verify this proposed solution. The hybrid algorithm presented here is original compared to previous studies. It is easy to understand, responds quickly, and can be implemented in systems with photovoltaic arrays of any size.
