Microsporidia are a group of obligate intracellular fungal pathogens with extremely wide host ranges. Among these, zoonotic microsporidia such as Encephalitozoon hellem, Encephalitozoon cuniculi, and Enterocytozoon bieneusi can infect humans as well as other animals, causing recurrent diarrhea, hepatitis, and even death in immune-compromised individuals. The abilities of zoonotic microsporidia to regulate their hosts are essential to their survival and thriving within hosts. The manipulations of zoonotic microsporidia on hosts are employed in multiple ways, including metabolic modulation, immune suppression, signaling pathway regulations, and epigenetic modification. This review focuses on pathogen-host interactions between zoonotic microsporidia and their hosts, and compares their regulatory characteristics with those of typical fungal pathogens such as Candida albicans. In summary, unraveling the regulatory strategies of zoonotic microsporidia not only deepens our understanding of microsporidia pathogenesis but also provides potential targets for therapeutic intervention against these emerging pathogens. Comparative studies with typical fungal pathogens further highlight the unique and sophisticated host-manipulating mechanisms evolved by microsporidia from the fungal kingdom.
Facing the multiple challenges brought about by global change and social development, this paper proposes the conceptual framework of “Holdiversity (和多样性)”, which defines human diversity, biological diversity, and environmental diversity as an interdependent, co-evolving, coupled system. This approach aims to systematically comprehend the synergistic mechanisms between humans and nature, facilitating the construction of trade-off strategies for sustainable development. Furthermore, this paper proposes that the watershed can serve as a fundamental operational unit for Holdiversity research. Its distinct natural boundaries and hierarchical structure enable it to effectively carry the spatial superposition and feedback coupling of multiple diversities. This concept aims to provide an integrated framework for interdisciplinary research and to offer a novel perspective on implementing the United Nations Sustainable Development Goals (SDGs).
Metallized biaxially oriented polypropylene (met-BOPP) is a flexible packaging material whose aluminium layer hinders mechanical recycling. This study presents a life cycle assessment (LCA) of a met-BOPP composite reinforced with cellulosic fibers, comparing its environmental performance to that of gypsum plasterboard, a conventional material widely used in drywall systems. The functional unit was defined as the production of 1 m2 of board. Primary data were obtained experimentally, and secondary data were sourced from the Ecoinvent 3.6 database, using OpenLCA 2.5 software and the ReCiPe 2016 Midpoint (H) impact assessment method. The results revealed substantially lower potential environmental impacts for the composite board compared to the gypsum plasterboard across several categories, with net environmental credits equivalent to 208% of the gypsum impact in Global Warming Potential, 460% in Marine Ecotoxicity, and 207% in Non-carcinogenic Human Toxicity. The environmental gains of the composite alternative result from the recycling of the post-consumer plastic waste used. A sensitivity analysis using a pure cut-off modelling, in which the met-BOPP waste enters the system burden-free and no valorization credits are granted, confirmed the environmental advantage of the composite in terms of GWP, showing a 90.8% reduction in GWP compared with gypsum plasterboard. These findings support met-BOPP composite panels as a promising low-carbon alternative for the construction sector, aligned with circular economy principles.
Tubulointerstitial fibrosis is a central pathological basis for the persistent progression of chronic kidney disease. Its initiation and progression involve multiple mechanisms, including disordered energy metabolism, lipid accumulation, inflammatory responses, and abnormal extracellular matrix deposition. As a major energy source for renal tubular epithelial cells, mitochondrial fatty acid oxidation (FAO) is essential for maintaining tubular metabolic homeostasis. Impaired FAO leads to insufficient ATP production, aggravated lipotoxicity, and mitochondrial homeostasis disruption, thereby further activating oxidative stress, inflammatory pathways, and profibrotic signaling, which, in turn, promote tubular injury and the progression of interstitial fibrosis. This review summarizes the basic physiological processes of mitochondrial FAO and its pathological role in tubulointerstitial fibrosis, with particular emphasis on the mechanisms by which FAO impairment drives metabolic reprogramming, lipotoxicity, and abnormalities in mitochondrial quality control. It also outlines recent advances in therapeutic strategies aimed at restoring FAO, improving mitochondrial function, and alleviating lipotoxicity and secondary profibrotic responses. Current evidence suggests that targeting FAO impairment may offer a promising therapeutic approach for delaying the progression of renal fibrosis; however, further efforts are needed to strengthen clinical translation.
Understanding how governance systems respond to ecological complexity requires analytical approaches that capture both biophysical interactions and stakeholders’ interpretations of causal relationships within socio-ecological systems. In the Eastern Mediterranean, the Indo-Pacific pearl oyster, Pinctada radiata, poses a governance challenge because it is simultaneously perceived as a non-indigenous species, an ecosystem engineer, and a livelihood resource. This study develops the Causal Cognitive–Institutional Architecture (CICA) for marine governance. Using Fuzzy Cognitive Mapping (FCM), it formalises stakeholder reasoning and socio-economic interactions. Stakeholder-specific causal maps were constructed for fishers, scientists, and government officials. The resulting models reveal distinct but complementary causal logics: fishers emphasise stewardship, collaboration, and livelihood security; scientists prioritise ecological stability, environmental change sensitivity, and habitat impacts; and government officials primarily emphasise regulatory coherence and enforcement. These stakeholder-specific maps were then integrated into a unified governance model using a weighted linear fusion procedure. The unified FCM identifies collaboration, community education, and environmental change sensitivity as highly influential cross-domain concepts, while institutional trust emerges as a fragile but consequential governance variable. Scenario simulations indicate that interventions targeting collaborative and learning-oriented mechanisms generate broader stabilising responses across the system than enforcement-centred interventions alone. The CICA–FCM framework provides a transparent diagnostic approach for identifying governance bottlenecks, integrating heterogeneous stakeholder reasoning, and supporting adaptive management of P. radiata under ecological uncertainty.
