Alterations of T Cell Subsets Associated with Sickle Cell Trait

Sickle cell trait (SCT) has been associated with alterations in various immune-related laboratory parameters including lower circulating lymphocyte counts. To further characterize the impact of SCT on the immune system, we performed flow cytometry of monocyte and lymphocyte immune cell subsets from peripheral blood mononuclear cells collected in a large, community-based cohort of SCT-positive (n = 68) and SCT-negative (n = 959) Black adults. SCT was significantly associated with lower proportions of CD8⁺ and CD4⁺ T cell subsets that include senescent-like markers of repeated immune system challenges. These immune alterations could have potential implications for the susceptibility of individuals with SCT to various infectious diseases.

Ecological Civilizations—A Development Narrative for the Global South?

We explore possibilities for the ecological civilization imaginary of China to become a sustainable development narrative shared by a growing number of GS nations. We first highlight the influence GS countries had on the evolution of the concept of sustainable development. GS nations’ interest in retaining economic development options, including energy and materials needed for industrialization and economic expansion, will increasingly contradict global environmentalist narratives of the latter half of the 20th century. The adaptation of GS nations to previously untested energy and material futures will depend on experimentation and learning from initiatives primarily designed and implemented by GS governments at the national, provincial, and local levels. If China succeeds in demonstrating practical examples of ecological civilization construction, it will stimulate other GS countries to learn and adapt lessons to suit their own needs. Multi-country arrangements that China has created could serve as forums to refine the ecological civilization narrative as a development alternative to the dualist conservation vs development thinking and practice of the latter half of the 20th century.

The Jerusalem Megalithic Rock Calendar Is an Identical Representation to That Found in Lanzarote Island (Canary Islands, Spain)

We have recently found that a megalithic basaltic rock lunisolar calendar in Lanzarote, Canary Islands (“Quesera or Cheeseboard” of Zonzamas) has almost a twin monument in Jerusalem (Al Quds in Arab). These two unique monuments are on the West and East sides of the Sahara Desert and support the hypothesis of a common “Green” Saharan culture and a later migration of people towards the Atlantic, Mediterranean, Middle East and other areas when desiccation started after 10,000 years BC, thus spreading culture and genes. Traces of this culture can still be found in Iberian rock inscriptions on the Canary Islands and in the Sahara Desert, particularly at Tim-Missaou in Algeria.This is concordant with Usko-Mediterranean languages (Basque and Berber are related and also with Iberian and Etruscan), genetics and other common anthropological traits. In this paper, we analyse the Al Quds-Jerusalem megalithic monument as representing a solar calendar of Egyptian-type (365 days in 1 year) and show how it could be identical to the Lanzarote megalithic calendar (“Quesera or Cheeseboard” of Zonzamas). Both monuments,each crest/channel, are coincidental in each solar month assignment in both Lanzarote and Jerusalem rock calendars representation. Jerusalem’s megalithic calendar was built at least 900 years BC, when it fell out of use. Therefore, it can be assumed that the Lanzarote megalithic calendar was constructed around a similar time, meaning an undetermined period over 2800 years ago.

Synthetic Biology in Nigeria: The Level of Awareness amongst Stakeholders

Synthetic biology, an emerging field at the intersection of biotechnology and engineering, has seen a global surge in application and awareness, necessitating a comprehensive understanding of its safe potentials to drive the bio-economy. This study aimed to assess the awareness and perceptions of synthetic biology among Nigerian biosciences stakeholders, including researchers, academicians, policymakers and students. The study employed a purposive online survey targeting diverse bioscience individuals and groups across Nigeria’s six geopolitical zones. The study received 107 responses from balanced gender representation with majority within the age group of 31–45 years old. The findings revealed a significant knowledge gap, with only 27.1% of respondents familiar with synthetic biology and 23.4% entirely unaware of it. Most respondents associated synthetic biology with biotechnology or genetic engineering and identified its applications to be in agriculture, medicine, environmental sustainability and research. Despite recognizing its benefits, many expressed concerns about safety, ethics, and regulation; notably, 43.9% of the respondents had concerns about synthetic biology with primary focus on safety and ethical implications. As regards the regulation of synthetic biology, the study showed that 80.4% of the respondents supported the need for synthetic biology regulation with few of the respondents (16.8%) aware of existing agency mandated to regulate synthetic biology. The respondents provided valuable insights into the various ways synthetic biology can be advanced in Nigeria which include increased awareness and capacity building, engagement through social media platforms, integration into education curricula and increased funding and investment in the research. The overall sentiment towards synthetic biology was positive, with 81.3% supporting its practice and 76.6% recognizing its positive global impact. However, a significant portion of respondents remained undecided. This study concludes that there is substantial gap in the knowledge of synthetic biology among bioscience stakeholders in Nigeria and the need for a heightened advocacy including continuous conferences and symposiums for the Nigeria bioscience community on the global potentials, concerns and regulation of synthetic biology. This will foster the acceptance of safe and responsible synthetic biology in Nigeria, thereby contributing to the broader national bio-economy development.

Reactions and Phase Transformations at Sintering of Cubic Boron Nitride Based Materials

Superhard cubic boron nitride (cBN) cutting materials with different contents of cBN were investigated. The compositions of cBN-based materials included ceramic and metallic binders. The sintering of materials was performed by high-temperature hot pressing (HPHT) six-anvil apparatus at pressure 4.5 GPa and temperatures 1400–1450 °C. The process of compaction and processing of superhard cBN materials is followed by numerous chemical reactions. The chemical reactions are very important in compaction and sintering. The volume transformations during chemical reactions affect the shrinkage of the materials and may also impact the residual porosity of the finished products. The adhesion between the grains also depends on these chemical reactions. The research analyzed the volume transformations of various reactions during HPHT sintering of cBN materials, which may play a significant role in forming their structure and properties.

Responsibility as Method—A Model for Operationalizing Ethical Reflection in the Sciences

In this article, we show why the growing significance of ethics entails that the call for ethical evaluations is no longer just a specific issue for the particular discipline of academic ethics but a challenge for all academic researchers. Therefore, complex theoretical approaches must be put into practice, and the relationship between ethics and other scientific fields must be clarified. Hence, this essay shows how these requirements can be fulfilled and how to cope with the complexity of ethical consideration on a practical level. We aim to operationalize responsibility as a method. In order to achieve this, basic criteria of practical ethical reflection are elaborated. As a result, we suggest an extended ethical matrix covering the entire research process using a step-by-step model. Our ethical matrix is designed to help researchers reflect and make judgments on moral and ethical issues, enabling them to find their own solutions to these challenges without providing a formal guideline for moral decision-making.

Numerical Investigation of a Point Absorber Wave Energy Converter Integrated with Vertical Wall and Latching Control for Enhanced Power Extraction

This study presents a numerical investigation of a point absorber wave energy converter (WEC) with a focus on improving its performance through the utilization of a vertical wall and latching control in the power take-off (PTO) system. Prior to numerical evaluations, experimental data incorporating PTO considerations and numerical simulation results were examined to validate the accuracy of the numerical methodology employed in this research. This study introduces a numerical PTO model and latching control for a further investigation. Comparative analyses were carried out on the displacement, velocity, and force of the PTO, absorbed power, and capture width ratio (CWR), considering the incorporation of a vertical wall and latching control. The results confirm that the introduction of both vertical wall and latching control significantly improves the CWR of the WEC, showing the effectiveness of incorporating a vertical wall and latching control in enhancing power extraction.

Evaluation of the Efficacy of Chinese Inactivated COVID-19 Vaccines against the Delta Variant in the Nanjing Outbreak: A Cohort Study

Background: The strains of COVID-19 are constantly mutating, and the effectiveness of Chinese inactivated vaccines against the COVID-19 Delta variant has not been described clearly. Methods: The clinical data of patients with the COVID-19 Delta variant in the 2021 Nanjing outbreak were retrospectively reviewed. Results: There were 212 patients with the COVID-19 Delta variant (unvaccinated, n = 56, 26.42%; vaccinated, n = 156, 73.58%) included in our cohort study. The median age was 45.5 (38, 53) years old. Eighty-seven subjects (41.04%) were airport staff, and 94 patients (44.34%) in 32 families were infected. There were 53 (25.00%) and 103 (48.58%) cases with one-dose and two-dose vaccination, respectively, and 55 (25.94%), 147 (69.34%) and 10 (4.72%) had mild, moderate and severe symptoms, respectively. The duration of viral shedding, or viral shedding time (VST), was significantly longer in unvaccinated individuals compared to vaccinated individuals (p = 0.0008). Moreover, the duration was significantly longer in patients who received one vaccine dose than those who received two doses (p < 0.0001). The mild patients had significantly shorter VSTs than the moderate subjects (p < 0.0001). Disease severity and vaccination dose were independent predictors for VST by Cox regression models. Conclusions: These results suggest that two-dose vaccination could reduce VST in patients with the COVID-19 Delta variant. Chinese inactivated vaccines may decrease the disease severity of cases with the COVID-19 Delta variant.

The Response of Vascular Endothelial Cells Post-Stroke and Its Role in Accelerating Atherosclerosis Progression

The Relationship between Negative Cognitive Processing Bias, Self-Control, and Depressive Symptoms among University Students: A Network Analysis

Background: Depression is a heterogeneous disease, with individual symptoms uniquely associated with negative cognitive processing bias and self-control. However, studies on the relationships among them from a fine-grained level are lacking. The present study employed network analysis to explore the specific connections among the three constructs based on the dual-process model. Methods: Recruiting 1168 Chinese university students, the study estimated a regularized partial correlation network. Depression, negative cognitive processing bias, and self-control were assessed with the nine-item Patient Health Questionnaire (PHQ-9), the Negative Cognitive Processing Bias Questionnaire (NCPBQ), and the Brief Self-Control Scale (BSCS), respectively. Results: Depression nodes fatigue, sad mood, and guilt were the most central symptoms. Negative memory bias, negative attention bias, and guilt were the bridge nodes. Network revealed distinct relations between different negative cognitive processing bias dimensions and depression symptoms, self-control and depression symptoms, and direct antagonistic effects between negative cognitive processing bias and self-control. Conclusions: The current study showed specific pathways between the three communities, and highlighted the role of dual-process model variables in depression development. Focusing on the identified critical depression nodes and related pathways could be effective for depression prevention and intervention.