The Himalayan region, known as the water tower of the Asian continent, boasts plenty of water. However, it faces acute water scarcity, particularly during the dry months from February to June. Traditional water sources were once the primary source of water in rural areas, but many have dried up, and some have vanished entirely. This paper examines potential of water resource and its conservation through traditional water practices in the Indian Central Himalaya. The study employs mainly a qualitative approach, collecting data from both primary and secondary sources. Primary data were gathered from 34 natural springs, including Naula, Dhara, streams/rivulets, Guls, and Khal-Chals, through a case study of 10 villages in the Pindar Valley. Furthermore, the characteristics and uses of these natural springs were illustrated. A total of 120 heads of households were interviewed about the status of water and its future potential, addressing perceptions of water availability, usage patterns, and water scarcity. The perception of these heads of households on the impact of climate change was noted. The author studied toposheets of the Survey of India and described the major rivers of the 13 districts of Uttarakhand. Data were also collected from the review of literature and the state water resource department, Dehradun. The study revealed that rural areas face acute water scarcity due to the drying of natural water sources. The tap water supply is insufficient, and during the rainy season, these pipelines are often damaged by flash floods and landslides. Large-scale sedimentation in the source area of tap water further hinders the water supply. The study suggests that reviving traditional natural water sources will help sustain water availability and supply.
Hard, brittle and difficult-to-machine materials are prone to surface cracks, subsurface damage and other defects in the traditional grinding process, accompanied by low processing efficiency and severe tool wear. As a new type of processing technology, energy field-assisted grinding provides a new approach for the efficient and high-quality processing of hard and brittle materials. This paper reviews the latest research progress of muti-energy field-assisted grinding from aspects such as the types and selection of grinding tools, processing equipment and physical-chemical coupled mechanisms. Firstly, micro-grinding tools are classified based on different surface structures and coating materials, with the aim to enhance processing efficiency, improve the surface quality and geometric accuracy of workpieces, and reduce tool wear. Secondly, the processing mechanisms, parameter selection and current difficulties faced by four energy field-assisted grinding methods, including laser-assisted grinding, electrochemical-assisted grinding, magnetic-assisted grinding and ultrasonic field-assisted grinding, are discussed under both chemical and physical effects. Thirdly, different equipment and auxiliary devices developed for energy field-assisted grinding have been introduced, providing reliable platforms for the distribution design and efficient regulation of the energy field. Finally, the cutting-edge progress, main challenges and development trends of energy field-assisted grinding are prospected, illustrating the great potential of this technology in fields such as aerospace, electronics, and optical components.
Global catastrophic infrastructure loss (GCIL) would disrupt energy supply networks, prohibiting heating in houses reliant on electricity or piped natural gas. In such situations, buildings in cold climates would require alternative heating methods, as space heating is critical to survival. This work assesses the viability of converting household appliances to wood-burning stoves and the scalability of such conversions in the event of a catastrophe. A standard residential electrical oven was converted to a wood-burning stove, using tools and materials likely to be readily available following GCIL, and tested by burning a total of 9.1 kg of pine wood and kindling. The conversion was successful, with an average useful heat output of 2.6 kW, showing the viability of ovens as wood-burning stoves for space heating. It is expected that such conversions could be completed in under one day, given sufficient availability of tools, materials, and labour. Global supplies of ovens, tools, materials, and fuel are expected to be sufficient for widespread conversion of ovens to wood-burning stoves, assuming international collaboration. However, international collaboration may be limited following GCIL, so countries should develop individual response plans accounting for this limitation, and knowledge should be disseminated ahead of time, or backup communication systems put in place.
A policy choice between migration prevention and migration support during climate variability needs to be properly backed by empirical evidence. The paper was to assess the effects of temporary migration on household adaptive capacity to climate variability (e.g., drought) in rural India. The analysis was performed by applying the propensity score matching method to the India Human Development Survey, 2011–12 data, and the India Meteorological Department’s gridded binary files. The household adaptive capacity to climate variability was measured in terms of three variables: monthly per capita consumption expenditure, livelihood diversity and the share of non-agricultural income. The study found that temporary migration had no statistically significant effect on household expenditure levels. The effect of temporary migration on livelihood diversity was found to be positive at 10% level of significance. The results suggest that temporary migration has significantly contributed to increasing the share of non-agricultural income. Results were similar even after removing the households with long-term migrant members from both treated and control groups. A disaggregated analysis across the different expenditure quintiles and social groups highlighted that the improved benefits of temporary migration, especially in terms of the share of non-agricultural income, were concentrated in certain groups only. The above results suggest that temporary migration may contribute to the development of household adaptive capacity in the face of climate variability (e.g., drought) not through the channel of utility maximization, but rather as a risk diversification strategy.
The FCC + BCC dual-phase solid solution structure was obtained in the Al0.1CoCrFeNi/304SS brazed joints using Ni/Al reactive multilayer nano-foils, which was proved by combining experiments with simulation. In this study, Finite Element Analysis was achieved to analyze the diffusion behavior across brazing joints, which were subsequently interrelated with the formation mechanism of the brazed micro-structures during the brazing process. During brazing, the joint interface is tightly bonded, and the atoms are diffused sufficiently to form the solid solution zone. The representative microstructure of the joint mainly comprised hard BCC (Al-Ni) + ductile FCC (Co-Fe-Cr) dual-phase. The successful use of nano-multilayer foils as a HEAs filler design can broaden the application range of HEAs and provide a novel procedure for brazing 304SS and Al0.1CoCrFeNi HEAs, and developing a novel field in the manufacture of HEAs-related joints.
Autoimmune encephalitis has reshaped the understanding of neuropsychiatric disorders by highlighting the role of autoantibodies in psychosis symptoms, which often mimic primary psychosis conditions. This review synthesizes recent research on autoimmune encephalitis-related psychosis, broadening the focus from humoral immunity to T cell autoimmunity and the communication between the peripheral and central nervous systems. We discuss the identification of neuronal antigen targets, particularly the N-methyl-D-aspartate receptor (NMDAR), and their involvement in disease pathogenesis. Current treatments, such as plasma exchange and intravenous immunoglobulin, primarily target the pathogenicity of autoantibodies. However, emerging evidence suggests a crucial role for T cells, glia cell, and B cell in the immunopathogenesis of autoimmune encephalitis-related psychosis diseases. Autoimmune factors, including T and B cells, can either infiltrate the brain from the periphery or propagate via interacting with other cells, like glia, within the brain itself. This review advocates for a comprehensive approach to studying and treating these conditions, integrating both humoral and cellular mechanisms.
Offshore Floating Photovoltaic structure (OFPV) represents a promising solar energy technology characterized by high conversion efficiency and suitability for large-scale deployment. However, the safety and economic synergy problems of floating structures restrict the industrialization and large-scale development of OFPV. We propose a novel OFPV with elastic connection and modularizable HDPE float blocks. The numerical wave tank is established by the turbulence model in FLOE-3D, based on the Navier-Stokes equations. Hydrodynamic analysis of the OFPV is conducted by using the Generalized Mode-Order (GMO) approach. Furthermore, the dynamic responses and mooring loads of the OFPV with elastic and rigid connections are compared. The results show that the average pressure of the photovoltaic support structure with the elastic connection is positively correlated with the wave height. The tension value of the elastic cable is higher at the outermost peak tension. The OFPV with the elastic connection structure has more obvious advantages in extreme wave state conditions than the rigid connection. This study provides theoretical support for the design and engineering application of OFPV.
The cyprinodontiform fish fauna of the Bangweulu–Mweru and Upper Lualaba freshwater ecoregions, situated in the uppermost Congo River drainage, has been reviewed. This study introduces four newly described species of seasonal Nothobranchius killifish and a novel species of lampeye belonging to the genus ‘Lacustricola’. Nothobranchius iridescens, new species, from the Kafila system in the Lufira drainage, is characterized in male colouration by anal fin with irregular red-brown spots and stripes, creating two irregular submedial and medial bands and with broad yellow subdistal band; and a caudal fin with a slender light blue subdistal band, densely marked with irregular red spots, and narrow dark brown distinct distal margin. Nothobranchius katemomandai, new species, from the Kay system in the upper Lualaba drainage, is characterized in male colouration by an anal fin with narrow brown submedial band, followed by a slender yellow band, a slender red-brown band and a slender dark brown distal band; and a caudal fin with brown spots proximally and medially, and with slender white to light blue subdistal band and a narrow dark grey distal band. Nothobranchius marmoreus, new species, from the Lufukwe system in the Lake Mweru basin, is characterized in male colouration by a body with irregular red-brown patches and stripes, forming a marble-like mottled pattern; and anal and caudal fins with slender yellow to amber subdistal band and broad dark brown distal band. Nothobranchius dubieensis, new species, from the Lubule system in the Luvua drainage, is characterized in male colouration by an anal fin with narrow dark brown submedial band, narrow yellow and orange medial bands, narrow white subdistal band, and slender dark brown distal band; and a caudal fin with irregular red-brown spots and stripes proximally and medially, followed by an irregular narrow red-brown subdistal band and slender white distal band, and with interrupted red-brown fin tips. ‘Lacustricola’ gemma, new species, from the Kay system in the upper Lualaba drainage, is characterized by a pattern of iridescent, diamond-shaped, light blue spots in scale centres below mid-longitudinal series on posteroventral portion of flank; median fins yellow to hyaline, with dark grey stripes perpendicular to fin rays; dorsal fin with light blue distinct margin; anal fin with dark grey margin. Analysis of mitochondrial COI gene sequences revealed that the five new species represent phylogenetically distinct lineages. These findings not only underscore their genetic uniqueness but also confirm their placement within the Nothobranchius brieni species group and the genus ‘Lacustricola’. Species of the genus Nothobranchius complete their seasonal life cycle in ephemeral natural habitats within freshwater wetlands, while ‘Lacustricola’ species migrate to breed in flooded areas of shallow, typically seasonal wetland habitats at the onset of the rainy season. These wetlands are highly vulnerable to a variety of human-induced stressors and threats, including agricultural cultivation, water extraction, urban expansion resulting in land-use pressure, and increased pollution, particularly from industrial activities such as mining. Therefore, it is essential to protect the integrity of these unique aquatic habitats throughout all the seasons of the year to maintain healthy wetland ecosystems and safeguard the distinctive seasonal freshwater biodiversity they support.
Fibroblast migration is a critical factor in wound healing, but also plays a fundamental role in fibrosis. For a fibroblast to migrate, the cell must be able to assemble factors that help it crawl across the extracellular matrix. Most of this movement is facilitated through the assembly and stability of the cytoskeleton that connects focal adhesion engagement with the extracellular matrix to intracellular stress fibers that wrap around the nucleus. These intracellular stress fibers help to polarize the fibroblast and orient the nucleus in the direction it is traveling. Changes in intracellular signaling for the fibroblast to move are also required, and this is necessitated by downstream signaling mediated by sonic hedgehog, WNT/β-catenin, ROCK/Rho, and PI3K/AKT. These changes regulate the stability of the cytoskeleton and, in addition, increase the expression of genes involved in cell migration. This review assimilates what is known about the function of the cytoskeleton in migration and the role of intracellular signaling pathways in fibrosis.
This study evaluated the clinical utility of the HEMOTAG™ recording device—A non-invasive, wearable system that measures cardiac time intervals (CTIs)—in managing patients with acutely decompensated heart failure (ADHF). The prospective, single-center study enrolled 105 patients, including those hospitalized with ADHF and a control group with non-HF-related conditions. Daily measurements of isovolumetric contraction time (IVCT), a key CTI marker, were collected using the HEMOTAG device and compared with NT-proBNP levels obtained on admission and day 3. Among ADHF patients, IVCT decreased in parallel with NT-proBNP levels, indicating volume status improvement with therapy. In contrast, the control group showed no significant change in IVCT or NT-proBNP. An IVCT ≥ 40 ms demonstrated strong sensitivity and specificity to detect ADHF (NT-proBNP ≥ 1800 pg/mL). These findings suggest that IVCT trends measured by HEMOTAG correlate with short-term treatment response in ADHF and could offer a non-invasive method to guide heart failure management. The technology demonstrated feasibility, safety, and clinical relevance, supporting its potential role in future remote management strategies.