Synthetic Biology and Engineering, Volume 1, Issue 3 (December 2023) – 5 articles

Metabolic engineering delivers an environmentally sustainable approach for the production of important compounds essential to pharmaceuticals, fuels, polymers, and various industries by leveraging renewable feedstock. Through a variety of techniques, including the modification or combining of existing metabolic pathways, redirection of metabolic flux, fostering co-cultures, protein engineering, and refining fermentation processes, microorganisms can be systematically reprogrammed to biosynthesize these products. This review provides insights into recent advances in the microbial production of various C5 and C6 chemicals, emphasizing both the accomplishments and challenges encountered.