Figure 2.
Overview of metabolic pathways extended from the shikimate pathway. Solid arrows signify direct steps. Dashed arrows represent multiple steps. Red X’s portray genes that are disrupted. Pink pathway corresponds to references [
34,
35,
96,
97,
98,
99,
100,
101,
102]. Purple pathway correlates to reference [
103]. Dark blue pathway corresponds to reference [
104]. Light blue pathway correlates to reference [
105]. Olive pathway corresponds to references [
106,
107]. Dark green pathway correlates to reference [
40]. Orange pathway corresponds to reference [
43]. Black arrows represent steps utilized by multiple pathways. E4P, erythrose-4-phosphate; PEP, phosphoenolpyruvate; DAHP, 3-deoxy-D-arabino heptulosonate-7-phosphate; DHS, 3-dehydroshikimate; CHR, chorismate; PHE, phenylalanine; TYR, tyrosine; TRP, tryptophan; PCA, protocatechuate; 4-HBA, 4-hydroxybenzoic acid; ISO, isochorismate; ANT, anthranilate; 2,3-DHBA, 2,3-dihydroxybenzoic acid; SA, salicylate; CA, catechol; MA,
cis,cis-muconic acid; AA, adipic acid; HMDA, 1,6- hexamethylenediamine; DHSD, 3-dehydroshikimate dehydratase; PCAD, protocatechuate decarboxylase; CPL, chorismate pyruvate lyase; HBAH, 4-hydroxybenzoic acid hydrolase; ICS, isochorismate synthase; IPL, isochorismate pyruvate lyase; SMO, salicylate 1-monooxygenase; DHBAD, 2,3-dihydroxybenzoic acid decarboxylase; AS, anthranilate synthase; ADO, anthranilate 1,2-dioxygenase; CDO, catechol 1,2-dioxygenase; ER, enoate reductase; CAR, carboxylic acid reductase; TA, transaminase.