This study examines the root causes of vibration and wear in centrifugal compressors, particularly emphasising strainer obstruction in hydrocarbon processing environments. Strainer fouling is primarily driven by deposits from inlet gas compositions and deviations in operating conditions, which restrict flow, increase vibration, and accelerate component degradation. A combined methodology was applied to investigate these issues, including baroscopic inspection of compressor internals, chemical analysis of deposited materials, and evaluation of operational records against design specifications. Maintenance histories and strainer cleaning frequencies were also reviewed to establish links between performance decline and operating practices. The findings show that chemical cleaning is the most effective and cost-efficient solution, outperforming high-pressure water jet cleaning and full compressor overhauls by minimising downtime, restoring flow dynamics, and improving mechanical stability. Successful implementation across multiple compressors confirmed its scalability and reliability. This research validates chemical cleaning as a preferred maintenance strategy, delivering significant operational and economic benefits while extending compressor service life.