Found 314 results
Open Access
Article
27 April 2025The Impact of Pacemaker Programming on Morbidity in Heart Transplant Recipients
Pacemaker programming recommendations in patients post-heart transplant include a higher lower rate limit, activating rate response mode, maximising battery longevity and minimising ventricular pacing in patients without atrioventricular block. This study sought to investigate how variability in pacemaker programming following orthotopic heart transplant affects morbidity. We conducted a retrospective analysis of heart transplant recipients at a single transplant centre between 1991 and 2023. Patients requiring pacemaker implantation following transplantation were matched with non-pacemaker recipients by age, sex and height. Patient and device characteristics were reviewed. Clinical outcomes, programming and physiological parameters were compared within the pacemaker group and between subject and comparator groups. Forty-five heart transplant recipients were included: 15 with pacemakers and 30 without. Within the pacemaker group, 20% were programmed with LRL > 60 bpm, rate-response mode in 47% and algorithms minimising ventricular pacing in 27%. Fifty-three percent were NYHA class I, and 46% NYHA class II; resting heart rate was similar between the groups (85 (SD14.9) and 79 (SD8) bpm: p = 0.33). NYHA class I group achieved a higher workload (METS 9 (SD2.7) vs. 6.9 (SD1) mL/kg/min: p = 0.21), and peak heart rate (135 (18.8) vs. 123 (14.8) bpm: p = 0.29) during exercise stress echocardiogram (ESE). The pacemaker group was more symptomatic than the comparator group (NYHA class II 46% vs. 10%: p = 0.016) and exhibited higher rates of cardiac allograft vasculopathy (53% vs. 10%: p = 0.005). There is substantial variability in pacemaker programming in heart transplant recipients. Patients who require a pacemaker have a greater symptom and comorbidity burden than those without. No identifiable physiological or programming differences stratified the greater morbidity within the pacemaker cohort.
Open Access
Review
27 April 2025Efficient Communication, the Lexicon, and Grammar
The driving forces behind language variation and change have long been a subject of debate. One prominent approach takes a functionalist perspective and posits that the need for efficient communication shapes lexical and grammatical patterns. This paper reviews five recent studies that offer further support for the plausibility of the communicative efficiency principle while also providing new insights into other factors that contribute to efficient linguistic structures. The key findings from these studies can be summarized as follows: (1) the principle of communicative efficiency offers plausible explanations for both lexical and grammatical phenomena, addressing both synchronic variations and diachronic changes in language evolution; (2) linguistic systems achieve efficiency through multiple mechanisms such as creation bias and selective pressures favoring efficient communication; (3) in addition to communicative efficiency, language evolution is also shaped by language history, with existing structures influencing subsequent ones. By synthesizing these studies, this paper underscores the efficiency account as a plausible and inclusive explanatory framework. It also stresses the need to rigorously delineate the role of communicative efficiency in language evolution, cautioning against automatically conflating the presence of efficient structures with intentional optimization for communicative goals.
Open Access
Article
25 April 2025Human Behavioral Ecology: Opportunities for Theoretically Driven Research on Human Behavioral Variation in China
Human behavioral ecology is an evolutionary framework that attempts to understand how adaptive human behavior maps on to variation in social, cultural, and ecological environments. It emerged as a coherent framework in the United States and the U.K. in the 1980s and has flourished as an explanatory framework ever since. The concentration of HBE scholarship in English-speaking countries has led to missed opportunities to engage other partners in testing and expanding human behavioral ecological models of human behavioral and life history variation. In this review, we provide a brief review of human behavioral ecology and describe opportunities for related scholarship in the Chinese context. We introduce human behavioral ecology holistically, including its history, methodological frameworks, pet topics, and recent integration with related fields, with a special emphasis on its recent integration with Chinese social, archaeological, and life sciences scholarship. We address potential criticisms of human behavioral ecology and how to ensure a robust and careful application of human behavioral ecology principles in the study of human behavior in China, past and present. We conclude with excitement as the remarkable variation in the Chinese behavioral landscape offers unparalleled opportunities for innovative and integrative studies.
Open Access
Article
25 April 2025The Crystal Structure of Apatite and Copper-Doped Apatite
The recent claim of superconductivity above room temperature in Pb10−xCux(PO4)6O, where 0.9 < x < 1 (referred to as LK-99), has generated significant interest. In this study, we first investigated the detailed crystal structures of four natural apatite by single crystal X-ray diffraction (SXRD) combined with a scanning electron microscope (SEM) equipped with energy dispersive X-ray spectroscopy (EDX) measurement. Secondly, pilot experiments of doping copper (Cu) atoms into the apatite lattice were carried out by high-temperature mixed pure copper and natural apatite powders. Finally, copper-doped lead apatite has been synthesized via a three-step solid-state reaction method, and its crystal structure has been determined using SXRD, SEM/EDX, and transmission electron microscopy (TEM).
Open Access
Article
23 April 2025Socio-Economic and Environmental Impacts of Jamrani Irrigation Dam Project, Kumaon Himalaya, India
This paper examines the economic and environmental impacts of the proposed Jamrani Irrigation Dam Project on the upstream and downstream areas. This study is primarily empirical, and a case study of six villages was conducted. A total of 415 households are being affected—fully and partially, due to the construction of the dam, out of which 122 heads of households were interviewed. A structured questionnaire was constructed, and the heads of households were asked about the socio-economic and environmental impacts of the proposed dam project. Furthermore, a detailed perception study of these households was conducted. Secondary data related to the size of the dam project, various land uses being affected by the dam, its socio-economic and environmental impact, and the most beneficial sectors were collected from the irrigation department, Government of Uttarakhand’s report 2020. In addition, socio-economic data from 415 households were collected from the same source. This study reveals that the dam project will have many favourable economic impacts in terms of supplying ample water for drinking and irrigation, electricity generation, development of infrastructural facilities and tourism, and the Gaula River flood control. On the other hand, the dam project will lead to land degradation, depletion of faunal and floral resources, soil erosion, and finally, the rehabilitation of the affected people. This study suggests that the proper use of technology and a suitable rehabilitation policy will make the project successful.
Open Access
Review
22 April 2025Counterfeit Drug Investigations: Techniques, Challenges, and the Role of Abductive Reasoning
Variable types of investigations exist regarding counterfeit drug detection, disruption, and regulation. Counterfeit drugs are spurious drugs, falsely labelled, falsified, substandard, unregistered/unlicensed, and infringe trademarks. Counterfeit drugs can mimic both legitimate and illegitimate drugs and are often distributed in virtual environments, such as illicit online pharmacies, the surface web, and the dark web. Counterfeit drug operators and operations are the typically corrupt and/or criminal individuals, groups, and techniques by which counterfeit drugs are produced and distributed. The manufacture and distribution of counterfeit drugs are ever-changing, which results in the need for investigative techniques that are equally adaptable and collaborative. Counterfeit drug investigations can be defined according to four categories: medical investigations in hospitals and through autopsies, chemical and non-chemical drug investigations in forensic toxicology laboratories, various track-and-trace technologies used in pharmaceutical industry investigations, and national and global coordinated investigations. Due to the diverse counterfeit drug investigations present, the logic and practice of abduction are highlighted as a primary part of the investigative element to counter ongoing efforts by offenders to evade detection. Abductive rationalities are prioritized in that they are contrary to an increasing reliance on technoscientific modes of data production alone. Rather, abductive reasoning plays a central role in counterfeit drug investigations at the levels of instigating and directing investigations, as well as interpreting and responding to evidential findings.
Open Access
Article
18 April 2025Factors Influencing the Incomes of Chinese Herdsmen in the Context of Grassland Ecological Compensation: A Meta-Analysis
This original paper, within the context of grassland ecological protection subsidies and reward policies, draws on 27 empirical studies conducted between 2011 and 2024 to conduct a meta-analysis of the factors influencing Chinese herdsmen’s incomes concerning heterogeneity and its sources. The results reveal 16 variables that have a significant positive impact on herdsmen’s incomes. These include herdsmen’s gender, age, ethnicity, level of education, household size, labor force, membership in cooperatives, subsidy amount, livestock quantity, living and production expenses, fixed assets, grassland area, per capita grassland area, grassland quality, and location. Among them, the quantity of livestock shows the greatest effect. Significant heterogeneity is evident across six variables: Subsidy amount, livestock quantity, grassland area, labor force, production expenses, and per capita grassland area. The heterogeneity in subsidy amount and grassland area originates from the use of different statistical methods, while the heterogeneity in livestock quantity is attributable to differences in the type of literature; per capita, grassland area heterogeneity is caused by differences in the geographical regions under analysis.
Open Access
Article
18 April 2025Strata Use in a Canopy Beetle Community of a Lowland Neotropical Rainforest in Southern Venezuela
Stratification of tropical rainforests and their arthropods is highly pronounced. I hypothesize that the occurrence of rainforest canopy beetles in the understory is not random but related to the ecology of the taxa, such as feeding guilds and larval development. Therefore, the ecological characteristics of stratum generalists recorded in both the canopy and the lower understory were analyzed. Adult beetles were collected manually and with traps in the northern part of the Amazonian rainforest for a cumulative year. Seventy out of a total of 862 canopy beetle species from 45 families associated with 23 tree species were shared between both strata. The beetle families represented by most species in the canopy and ground samples were Curculionidae, Chrysomelidae, and Carabidae. For Elateridae and Scarabaeidae, the proportion of shared species between the strata was ≥20%. In contrast, the species-rich families (≥20 canopy species) Cerambycidae, Mordellidae, and Buprestidae did not comprise species sampled in both strata. Thus, beetle families comprising many stratum generalists are either largely predatory, or their larvae often develop in the soil.
Open Access
Review
17 April 2025Advances in Cardiac Resynchronisation Therapy
Cardiac resynchronisation therapy (CRT) has emerged as a transformative treatment in heart failure management, particularly for patients with significant left ventricular systolic dysfunction in the context of electrical dyssynchrony. Over time, CRT has evolved to address broader patient populations and more complex clinical scenarios. Despite its well-documented benefits in improving survival, reducing hospitalisation and enhancing quality of life, approximately 30% of patients fail to respond, making ongoing research critical for optimising outcomes. This review provides a comprehensive update on the evolving landscape of CRT therapy. Focus is placed on expanding indications, novel assessment techniques for dyssynchrony, application in special populations and innovations in device programming.
Open Access
Article
15 April 2025Technical and Eco-Efficiency Implications of the Use of Basalt Fibre in Hybrid Composites
The use of hybrid composites can be environmentally friendlier than the traditional materials since renewable resources, both natural and synthetic fibres can be incorporated into the composites, resulting in lighter weight, enhanced resource efficiency, durability, and biodegradability, which could potentially make them sustainable materials for structural applications. Basalt fibre being treated with hydrochloric acid exhibits superior adhesion with the epoxy matrix, improving overall strength and stiffness. Thus, the aim of this paper is to determine the eco-efficiency of two types of hybrid composites: glass/basalt and carbon/basalt fibre-reinforced under flexural loading. The flexural strengths of these composites were obtained through a Finite Element Analysis (FEA) model using Ansys workbench. These simulation-based flexural strengths form the basis for the quadratic regression model to establish a relationship between the different flexural strengths and fibre volume fractions combinations. Given the required flexural strength between 900 and 1300 MPa, the optimal candidates/layups were identified with the aid of the model. An environmental study following a life cycle assessment (LCA) and eco-efficiency framework of unidirectional glass/basalt and carbon/basalt fibre-reinforced hybrid composites with varying fibre volume fractions is presented in this paper to select the eco-efficient composites. In the case of glass/basalt fibre-reinforced hybrid composites, the designs with the highest eco-efficiency for 900 and 1200 MPa are [BG3]S with more glass fibre and [G7B] with more glass fibre, respectively, due to having lower costs and environmental impacts. For carbon/basalt fibre-reinforced composites, the stacking sequence [B8] was deemed to be the most eco-efficient. Finally, epoxy has the highest economic and environmental cost. Therefore, composite designs with high glass fibre content are considered eco-efficient since they have a lower epoxy content.
