Artiles
Open Access
Article
07 August 2024Airway Serous Cells: A Comparative Study of Spatial Distribution and Abundance among Species
The conducting airways of the respiratory system play a crucial role in filtering, humidifying, and directing air into the lungs. Among the specialized cell types within these airways, airway serous cells are notable for their secretion of watery, protein-rich fluids and enzymes, which contribute to maintaining airway surface liquid homeostasis and defending against pathogens. However, the distribution and abundance of serous cells across different species in the conducting airways remain poorly understood. In this study, we addressed this gap by investigating the spatial distribution of the airway serous cell-specific marker BPI fold containing family A member 1 (BPIFA1) in humans, pigs, and mice. Our findings demonstrate significant variations in the distribution and abundance of serous cells among these species, potentially reflecting their different respiratory anatomy and evolutionary adaptations to diverse environmental challenges and respiratory demands. In humans and pigs, airway serous cells are predominantly found in the submucosal glands of the trachea and segmental bronchi, frequently overlapping with lysozyme-positive secretory cells. In contrast, rodents like mice exhibit a distinct pattern where serous cells are scarce in submucosal glands. Instead, rodent serous cells are primarily located at the epithelial surface from the trachea to the main bronchi, where many co-express the Club cell-specific protein SCGB1A1. The abundance of serous cells diminishes progressively in the intrapulmonary airways. Given that rodent models are widely utilized in respiratory research, understanding anatomical and cellular differences in airway serous cells is critical for interpreting experimental outcomes and translating findings to human respiratory diseases and therapeutic strategies. This comparative analysis enhances our understanding of airway biology across species and informs the selection and interpretation of animal models in respiratory studies.
Open Access
Article
06 August 2024Evaluation of a Present-Day Thermal Activity on the Constitutive Minerals of a Granite and of Its Impact on the Whole-Rock Sealing Potentials
Mineralogical and chemical analyses of the major constitutive minerals from granite des Crêtes collected near the thermal site of Plombières-les-Bains (Vosges Mountains, eastern France) clearly show that recently circulating thermal waters up to 90 °C do not impact them. Even the constitutive minerals smaller than 2 microns are not affected. As a result, all minerals reflect the entire complex tectonic-thermal history of the granitic massif rather than just the recent thermal impact. Only the open faults and natural drains contain calcite from recent thermal waters. This is confirmed by similar calcite deposits with the same elemental contents sampled in the pipes of thermal installations. As a complementary conclusion, storage of containers of nuclear waste that diffuse an overall temperature up to 100 °C will not alter the potential sealing properties of a plutonic host massif, of course, without any recent thermal drainage that could potentially spread radioactive waste. This conclusion was already obtained on a moderately faulted sedimentary environment after a one-year in-situ heating experiment at about 100 °C. Calcium is a key indicator of low thermal impact. After an initial decrease, its levels rose significantly in the most "altered" granite samples, inducing calcite precipitation, even in the water pipes at the thermal site. The negligible impact of a hydro-thermal activity at a maximum of about 100 °C in a granitic material represents, indeed, a piece of useful information, as deep sites for nuclear waste in plutonic host rocks appear to act, also, as potential isolated host systems.
Open Access
Review
06 August 2024Considerations for Unmanned Aerial System (UAS) Beyond Visual Line of Sight (BVLOS) Operations
This paper, intended for expert and non-expert audiences, evaluates the technical and regulatory requirements for Unmanned Aerial Systems (UAS) to operate beyond visual line of sight (BVLOS) services. UAS BVLOS operations have the potential to unlock value for the industry. However, the regulatory requirements and process can be complex and challenging for UAS operators. The work explored the BVLOS regulatory regime in the UK, Europe and the US and found similarities in process and requirements covering themes like Detect and Avoid (DAA), Remote identification and Reliable Connectivity. A unifying goal across these jurisdictions is to operate BVLOS safely and securely in non-segregated airspace. However, operating BVLOS in segregated airspace as the default or routine mode could accelerate approval and adoption. The paper reviewed existing challenges, highlighting Coverage, Capacity and Redundancy as critical for UAS BVLOS Operations. The work also highlighted the crucial role of Non-terrestrial Network (NTN) assets like Satellites and HAPS (High Altitude Platform Station) since terrestrial networks (not optimised for aerial platform coverage) may not be reliable for BVLOS connectivity.
Open Access
Article
05 August 2024Promoting Ecological Civilization through Religious Prophetic Communication: An Interreligious Framework
This paper explores the transformative potential of religious prophetic communication in advancing an ecological civilization. Drawing upon diverse religious traditions—Christianity, Islam, Buddhism, and Confucianism—it argues that religious teachings offer profound insights and ethical frameworks essential for addressing contemporary ecological challenges. A key aspect of ecological civilization is the presence of a pervasive ecological ethos. The paper contends that religious prophetic communication plays a crucial role in cultivating such an ethos by promoting a heightened ecological conscience and consciousness among individuals and communities. Through prophetic communication, faith actors and communicators articulate moral imperatives rooted in religious principles contextualized to the present ecological situation. The paper delineates five components that make up religious prophetic communication: (1) Communicating from the position of faith; (2) Communicating in a contextually relevant manner; (3) Communicating to energize; (4) Communicating to criticize; and (5) Communicating beyond words. Applied to the ecological context, religious prophetic communication aims to affirm, stimulate imagination, clarify misunderstandings, inspire action, and confront unjust realities. By carrying out its prophetic role, religious communicators can help bring about an ecological ethos and promote the realization of ecological civilization.
Open Access
Review
02 August 2024A Promising and Forward-Looking Advancement Using Drones: Perspectives from Indian Sericulture
Drone integration in sericulture marks a promising advancement within the sector, leveraging recent technological strides in unmanned aerial vehicles (UAVs) across various industries like agriculture and healthcare. While the adoption of drones in sericulture remains nascent, their potential benefits, particularly in chemical spraying tailored to sericulture’s unique environmental conditions, are increasingly recognized. This paper explores the efficacy of drone-based pesticide spraying and smart fertilization methods optimized for sericulture settings. The rapid deployment capabilities of drones facilitate enhanced network connectivity, potentially catalyzing rural development and economic prosperity within the sericulture community. However, ethical and operational concerns persist regarding drone use across industries, necessitating robust regulatory frameworks and ethical guidelines. Furthermore, advancements in artificial intelligence augment drone capabilities, enabling automated inspections and improved performance across diverse applications. This paper underscores the need for further research and the development of standardized operating protocols to harness the transformative potential of drone technology in sericulture. Key focus areas include optimizing pesticide delivery, ensuring environmental sustainability, and addressing ethical considerations surrounding drone utilization. By leveraging UAVs for precision spraying and smart fertilization, sericulture stands poised to enhance productivity, bolster economic development, and navigate emerging challenges in agricultural production.
Open Access
Article
26 July 2024Current and Future Costs of Storage for Electricity in a Decarbonized Electricity System
As power systems globally are transitioning from fossil fuels to renewable sources, integrating energy storage becomes imperative to balance variable renewable electricity generation. The core objective of this paper is to conduct a comprehensive cost assessment of selected energy storage technologies from 2023 to 2050, focusing on the Austrian electricity market. Our method combines techno-economic assessment with the technological learning method to integrate various storage technologies into a renewable electricity system, using scenarios that account for decarbonization goals. Results indicate that pumped storage hydro exhibits none or negative learning effects, while lithium-ion batteries demonstrate significant investment cost decreases. Despite investment cost reductions, underground hydrogen storage continues to incur high total costs per kWh discharged due to low roundtrip efficiency, suggesting its future outlook depends on seasonal storage needs in fossil-free power systems. An important finding of this analysis underscores the importance of optimizing the ratio of electricity demand, renewable generation expansion and storage deployment for cost-effectiveness. Excessive storage deployment leads to lower utilization and higher costs, emphasizing the necessity of at least 1500 full-load hours for profitable operation across all storage systems. Strategic planning for optimal storage deployment is emphasized to optimize utilization and minimize costs.
Open Access
Communication
26 July 2024The Project of Constructive Anthropology in Russian Empiriocriticism
The article analyzes the main provisions of constructive anthropology developed in Russian empirio-criticism in the first quarter of the 20th century. The justification of non-metaphysical philosophy, which developed the “problematic” approach to cognition, made the new understanding of man possible. From this point of view, the essence of man is not a metaphysical constant, but is modeled on the basis of an appropriate organization of experience; the essence of man is determined by his existence and is constantly changing; the essence of man can be consciously adapted by directing his development and giving him the necessary characteristics; man as an essence is always man’s project, or scientific and philosophical concept; only by understanding man as a dynamic project can we justify free will and man’s capacity for creation. The project of constructive anthropology is fundamentally different from the philosophical anthropology developed in Germany in the 20th century by Max Scheler and Helmuth Plessner, since the latter is essentially an attempt to preserve the traditional metaphysical interpretation of man.
Open Access
Article
25 July 2024A Distributed Framework for Persistent Wildfire Monitoring with Fixed Wing UAVs
Wildfires have proven to be a significantly exigent issue over the past decades. An increasing amount of research has recently been focused on the use of Unmanned Aerial Vehicles (UAVs) and multi-UAV systems for wildfire monitoring. This work focuses on the development of a decentralized framework for the purpose of monitoring active wildfires and their surrounding areas with fixed wing UAVs. It proposes a distributed fire data update methodology, a new formation algorithm based on virtual forces, fine-tuned by a Genetic Algorithm (GA), to arrange virtual agents into the monitoring area, and a control strategy to safely and efficiently guide fixed wing UAVs to loiter over the structured virtual agents. The system is tested in Software In The Loop (SITL) simulation with up to eight UAVs. The simulation results demonstrate the effectiveness of the system in monitoring the fire in a persistent manner and providing updated situational awareness data. The experiments show that the proposed framework is able to achieve and maintain coverage up to 100% over the area of interest, and very accurate fire representation. However, the performance is decreased for the experiments with low UAV numbers and large fire sizes.
Open Access
Article
22 July 2024Aging-Associated Molecular Changes in Human Alveolar Type I Cells
Human alveolar type I (AT1) cells are specialized epithelial cells that line the alveoli in the lungs where gas exchange occurs. The primary function of AT1 cells is not only to facilitate efficient gas exchange between the air and the blood in the lungs, but also to contribute to the structural integrity of the alveoli to maintain lung function and homeostasis. Aging has notable effects on the structure, function, and regenerative capacity of human AT1 cells. However, our understanding of the molecular mechanisms driving these age-related changes in AT1 cells remains limited. Leveraging a recent single-cell transcriptomics dataset we generated on healthy human lungs, we identified a series of significant molecular alterations in AT1 cells from aged lungs. Notably, the aged AT1 cells exhibited increased cellular senescence and chemokine gene expression, alongside diminished epithelial features such as decreases in cell junctions, endocytosis, and pulmonary matrisome gene expression. Gene set analyses also indicated that aged AT1 cells were resistant to apoptosis, a crucial mechanism for turnover and renewal of AT1 cells, thereby ensuring alveolar integrity and function. Further research on these alterations is imperative to fully elucidate the impact on AT1 cells and is indispensable for developing effective therapies to preserve lung function and promote healthy aging.
Open Access
Review
19 July 2024Solid Additives to Increase the Service Life of Ceramic Cutting Tool: Methodology and Mechanism
With the development of the manufacturing industry, there is an increasing demand for high-efficiency processing, high-precision processing, and high-temperature processing. The characteristics of ceramic tools, such as high hardness and wear resistance, make them suitable for high-precision processing. Additionally, their excellent high temperature resistance perfectly meets the requirements of high temperature processing. However, ceramic tools have a relatively low strength and are prone to breakage, which limits their application in some high-strength machining fields. Their low toughness and brittleness also lead to easy cracking and reduced tool life, resulting in frequent tool changes that further limit processing efficiency. Therefore, improving the service life of ceramic tool materials is crucial to enhance processing efficiency and achieve significant economic benefits. With the development of material science, solid additives with toughening and strengthening properties have greatly improved the performance of ceramic tool materials and given ceramic tools new life-enhancing properties, such as lubrication and repair. By utilizing the combined action of one or more solid additives and employing surface coating technology, the service life of ceramic cutting tools is significantly extended. This makes the application of ceramic tools in industrial cutting more and more widely, and the demand is also growing rapidly. However, the mechanism and methods of various solid additives to increase the life of ceramic tool materials have not been systematically reviewed. The analysis of the composition and functional properties of ceramic tool materials was used as a basis to summarize the mechanism by which various solid additives improve the service life of ceramic tool materials, and to provide points for attention in their use. The aim is to assist researchers in designing and preparing new ceramic tool materials that can meet processing requirements. Finally, the research status, challenges, and prospects of enhancing the service life of ceramic cutting tools with solid additives are summarized, providing a foundation for further research.
