Found 381 results
Open Access
Article
01 April 2024Identity, Secondary Vocational Education Options and Return on Investment: Evidence from Children of Rural Chinese Families
With the continuous improvement of living standards, the importance of educational choice becomes more and more prominent. Based on the data of China General Social Survey (CGSS), a simultaneous equation model of identity, secondary vocational education choice and investment return is constructed. On the basis of fully considering endogeneity and sample selection bias, this paper analyzes the influence of identity on secondary vocational education choice and investment return by means of instrumental variables and propensity score matching (PSM). It is found that class differentiation is the main factor affecting class identity. The more blurred class differentiation, the higher class identity. Class identity has a significant positive impact on identity. The higher class identity, the easier it is to form identity. Identity has a direct positive impact on personal investment return. The stronger the identity, the higher the investment return. At the same time, identity has a significant positive impact on the choice of secondary vocational education. The stronger the identity, the more inclined to choose secondary vocational education. Compared with individuals with junior high school education, individuals with secondary vocational education have a higher return on education investment. Therefore, identity can not only directly improve an individual’s return on investment, but also improve the possibility of an individual’s choice of secondary vocational education, thereby improving an individual’s return on education investment, and ultimately increasing an individual’s return on investment.
Open Access
Article
31 March 2024
The Asthma Risk Gene, GSDMB, Promotes Mitochondrial DNA-induced ISGs Expression
Released mitochondrial DNA (mtDNA) in cells activates cGAS-STING pathway, which induces expression of interferon-stimulated genes (ISGs) and thereby promotes inflammation, as frequently seen in asthmatic airways. However, whether the genetic determinant, Gasdermin B (GSDMB), the most replicated asthma risk gene, regulates this pathway remains unknown. We set out to determine whether and how GSDMB regulates mtDNA-activated cGAS-STING pathway and subsequent ISGs induction in human airway epithelial cells. Using qPCR, ELISA, native polyacrylamide gel electrophoresis, co-immunoprecipitation and immunofluorescence assays, we evaluated the regulation of GSDMB on cGAS-STING pathway in both BEAS-2B cells and primary normal human bronchial epithelial cells (nHBEs). mtDNA was extracted in plasma samples from human asthmatics and the correlation between mtDNA levels and eosinophil counts was analyzed. GSDMB is significantly associated with RANTES expression in asthmatic nasal epithelial brushing samples from the Genes-environments and Admixture in Latino Americans (GALA) II study. Over-expression of GSDMB promotes DNA-induced IFN and ISGs expression in bronchial epithelial BEAS-2B cells and nHBEs. Conversely, knockout of GSDMB led to weakened induction of interferon (IFNs) and ISGs in BEAS-2B cells. Mechanistically, GSDMB interacts with the C-terminus of STING, promoting the translocalization of STING to Golgi, leading to the phosphorylation of IRF3 and induction of IFNs and ISGs. mtDNA copy number in serum from asthmatics was significantly correlated with blood eosinophil counts especially in male subjects. GSDMB promotes the activation of mtDNA and poly (dA:dT)-induced activation of cGAS-STING pathway in airway epithelial cells, leading to enhanced induction of ISGs.
Open Access
Article
25 March 2024Proteomic Analysis of Pleurotus ostreatus Grown on Glucose and Xylose Mixtures in Submerged Fermentation Provides Insights into Differentiated Mycelial Composition
Pleurotus ostreatus, an edible white-rot fungus of great commercial and nutritional value, grows by metabolizing mainly glucose and xylose, the two major sugars in lignocellulosic biomass. In this study, a comparative proteomic analysis of P. ostreatus grown in submerged fermentation on a medium with glucose, xylose and mixtures of them as carbon sources was conducted. In the same conditions, the metabolic response of the fungus was evaluated in the production of the main nutritional components of the fungus such as proteins, lipids, and intracellular and extracellular polysaccharides. The proteomic analysis revealed that glucose and xylose upregulate different clusters of proteins. Glucose mainly up-regulates macromolecule metabolic processes, translation and glycolysis whereas xylose up-regulates, small molecule metabolic processes and tricarboxylic acid cycle (TCA). The mixtures show mostly similarities with the proteome response to glucose, although there are differential responses depending on xylose concentration. The carbon source type found to affect the basic macromolecule metabolic processes, with amino acids biosynthesis to differentiate mostly. An analysis of the upregulated proteins through the STRING database revealed that xylose upregulates mostly proteins related to amino acid biosynthesis. Leucine, Valine and Isoleucine biosynthesis pathways were found to be the most triggered pathway. All the branched-chain amino acids (BCAAs)-related enzymes intensities were gradually increased when xylose concentration was increased in the growth medium. BCAAs play an important role in the human diet so the enhancement of BCAAs biosynthesis pathway for P. ostreatus could convert it to a very remarkable protein substitute in human diet. These findings provide new insights into the proteomic and metabolic response of the fungus to the major sugars of lignocellulosic biomass, which are not well understood until now.
Open Access
Article
22 March 2024Community Sport, Australian Sport Policy and Advocacy: A Qualitative Study of Stakeholder Perspectives
This article explored aspects of the community sport policy process in rural New South Wales, Australia, focusing on the views of community sport club (CSC) officials relating to policy matters. Community sport represents a complicated policy arena, and rural communities face a level of disparity compared with better-resourced urban CSCs, particularly concerning policy implementation and advocacy issues. Officials at CSCs from ten different sports (n = 10) in a rural setting participated in semi-structured interviews to pinpoint themes common in the community sport policy process. Further, the research identified aspects of the connections that impact CSCs, including those with government and National Sporting Organisations (NSOs). To highlight the beliefs and attitudes of the CSC officials, the interviews had two key thematic foci—implementation and advocacy—and the findings highlighted sub-themes relating to the fundamental interests of CSCs. Overall, the research accentuated the hierarchical nature—a power imbalance—of sport policy processes, the potential for CSCs to have a bottom-up role in policy creation, and the consideration of a policy analysis and evaluation structure such as the Advocacy Coalition Framework. Finally, the outcome points to enthusiasm for strengthening community sport by giving CSCs a voice through localized advocacy.
Open Access
Article
19 March 2024Designing a Quadcopter for Fire and Temperature Detection with an Infrared Camera and PIR Sensor
In agriculture, medicine, and engineering, sudden fire outbreaks are prevalent. During such events, the ensuing fire spread is extensive and unpredictable, necessitating crucial data for effective response and control. To address this need, the current initiative focuses on utilizing an Unmanned Aerial Vehicle (UAV) with an Infrared (IR) sensor. This sensor detects and analyses temperature variations, accompanied by additional camera footage capturing thermal images to pinpoint the locations of the incidents precisely. The UAV’s programming is executed using Arduino-Nano and mission planner software, interfacing with the Pixhawk flight controller operating in a guided mode for autonomous navigation. The UAV configuration includes a radio module interfacing with Arduino-Nano, a flight controller, and remote-control functionality. The flight duration is approximately 10–15 min, contingent upon flight dynamics and environmental temperature. Throughout its airborne operation, the UAV transmits live telemetry and log feeds to the connected computer, displaying critical parameters such as altitude, temperature, battery status, vertical speed, and distance from the operator. The Pixhawk flight controller is specifically programmed to govern the UAV’s behavior, issuing warnings to the pilot in case of low voltage, prompting a timely landing to avert potential crashes. In case of in-flight instability or a crash, the mission planner can trace the UAV’s location, facilitating efficient recovery and minimizing costs and component availability losses. This integrated approach enhances situational awareness and mitigation strategies, offering a comprehensive solution for managing fire incidents in diverse fields.
Open Access
Review
29 February 2024Conceptualizing an Informational Paradigm in the Pursuit of Sustainable Cities and Communities
This study seeks to conceptualize ‘Informational Sustainability’ by examining the dynamic relationship between Sustainable Development and the Information and Communication Technologies (ICT) Revolution through the exploration of two prominent urban theories—Lefebvre’s ‘Right to the City’ and Castells’ ‘Rise of the Network Society’—to underscore the importance of knowledge integration in the development of informed, sustainable communities. Conducting a cross-country comparison between developed and developing nations, the study underscores the critical role of informational transformation in enabling resource efficiency, knowledge sharing, innovation, and informed decision-making—key for achieving Sustainable Development Goals (SDGs), while also highlighting potential risks associated with resisting ICT adoption, including hindered growth, increased inequalities, and reduced social engagement and environmental stewardship. The core focus of this conceptual framework is to validate the precursor role of ICT in building sustainable cities and communities by identifying synergies in Sustainable Development, defining dimensions for effective ICT application within the dynamic interplay of global and local levels, and identifying implementation gaps and necessary presumptions for its effective use.
Open Access
Article
27 February 2024Knowledge-data Collaborated Digital Twin Model of Papermaking Process
The structure of the drying section in papermaking process is complex and too compacted to install sensors. In order to monitor the parameters in dynamic and manage the process practically with virtual simulations instead of physical experiments, a digital twin-based process parameter visualization model is constructed in this study. Regarding to the possible missing data in the modeling framework, it is proposed to combine industrial data, and knowledge of mechanism with intelligent algorithms to fill in the missing parameters. Upon which, a digital twin-based data visualization model is established using CADSIM Plus simulation software. Both of the knowledge -based mechanism solution model and the random forest-based parametric prediction model perform well, and the predicted parameters can support the digital twin visualization model in CADSIM Plus. Visual modeling of surface condenser in the paper drying section was realized for example, and results show that the model is capable of monitoring the dynamic changes of parameters in real time, so as to support the optimization and decision making of papermaking process such as formation, drying, et al.
Open Access
Case Report
26 February 2024‘Greening’ an Oil Exporting Country: A Hydrogen and Helium Closed-cycle Gas Turbines Case Study
Holistic decarbonisation requires collaborative efforts and substantial investments across diverse economic sectors. This study introduces an innovative national approach, blending technological insights and philosophical considerations to shape decarbonization policies and practices. Libya is the case study. The proposed framework involves submersible power stations with continuous-duty helium closed-cycle gas turbines to supply electricity demand and hydrogen. Extensive national data is analysed, incorporating factors such as sectoral consumption, sea temperature, and port locations. An analytical model is developed, providing a valuable foundation for realistic decarbonization scenarios. The model aims to maintain the benefits of current energy consumption, assuming a 2% growth rate, while assessing changes in a fully green economy. The results offer qualitative and quantitative insights on hydrogen use and an expected rise in electricity demand. Two scenarios are examined: self-sufficiency and replacing oil exports with hydrogen exports. This study provides a quantitative perspective on decarbonization, focusing on a submersible helium closed cycle gas turbine concept resistant to natural disasters and proliferation. Findings underscore the substantial changes and investments needed for this transition, identifying primary needs of 27 GW or 129 GW for self-sufficiency and exports, respectively. This foundational analysis marks the start of research, investment, and political agendas toward decarbonization.
Open Access
Review
23 February 2024Research Status and Prospect of Ultrasonic Vibration and Minimum Quantity Lubrication Processing of Nickel-based Alloys
Nickel-based alloys has important application value in modern industrial field, but there are a lot of problems that are difficult to solve in traditional processing, and it is a typical difficult-to-process material. In order to improve the machinability of nickel-based alloys, scholars try to use a variety of non-traditional processing methods to explore and study the processing of nickel-based alloys. In these studies, ultrasonic vibration assisted processing technology and minimum quantity lubrication (MQL) processing technology can achieve remarkable results. The intermittent separation cutting characteristics of ultrasonic vibration assisted processing technology can improve the processing quality by changing the tool path, while minimum quantity lubrication processing technology can improve the lubrication effect of cutting, combining ultrasonic vibration assisted MQL processing leverages the benefits of both methods, resulting in improved machinability and expanded application of nickel-based alloys. Summarize the current research status on the machining mechanism of nickel-based alloys assisted by ultrasonic vibration and micro lubrication, and anticipate its developmental trends. This provides a reference for future research on the efficient machining mechanisms and practical applications of nickel-based alloys.
Open Access
Article
23 February 2024Influence of Separation Gap on the Performance of Savonius Hydrokinetic Turbine
Despite that ocean current energy is one of the promising sources of electricity produced in the ocean, the development of ocean current energy is far behind compared to other ocean energy due to the low efficiency and high cost of installation and maintenance. Among many converting devices, the Savonius turbine has been proven to be effective and competitive in harnessing ocean current energy. The primary purpose of the present study is to search for the optimum shape of a Savonius rotor based on CFD simulation (Star-CCM+). A Savonius turbine composed of two rotating cup-shaped rotors is selected as a numerical model. We focus on the effect of two geometry parameters such as the overlap and gap ratio on the power coefficient. Throughout the parametric study, the shape of a Savonius rotor affects the power performance, and two geometry parameters with an overlap ratio of 0.15 and a gap ratio of −0.03 are found to be the optimum design. It demonstrates stable performance within the wide TSR (Tip Speed Ratio) range of 0.6 to 1.6, with the maximum power coefficient Cp of 0.34 achieved at a TSR of 0.8. According to the numerical results based on the new CFD model, the presence of a bottom wall does not significantly affect the performance of a Savonius turbine. It means that the present unbounded CFD model can be acceptable in the initial design stage for the determination of the geometry parameters of a Savonius turbine.
