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Beneficial Effects of Food Containing Lactononadecapeptide on Memory Function in Elderly Japanese Subjects—A Randomized, Double-Blind, Placebo-Controlled Study

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Beneficial Effects of Food Containing Lactononadecapeptide on Memory Function in Elderly Japanese Subjects—A Randomized, Double-Blind, Placebo-Controlled Study

Shizuo Yamada 1,* Michiyo Shirai 1 Fumiya Nakamura 2 Kazuhito Ohsawa 2 Manabu Watanabe 3 Michiko Koga 3
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1
Center for Pharma-Food Research, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
2
Core Technology Laboratories, Asahi Quality & Innovations, Ltd., Ibaraki 302-0106, Japan
3
Sunkokai Medical Corporation, Koga Community Hospital, Shizuoka 410-0638, Japan
*
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Received: 08 December 2025 Revised: 20 January 2026 Accepted: 02 March 2026 Published: 13 March 2026

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© 2026 The authors. This is an open access article under the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

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Food Res. Suppl. 2026, 1(2), 10006; DOI: 10.70322/frs.2026.10006
ABSTRACT: With the extension of average life expectancy, diseases accompanied by cognitive and memory impairments, such as dementia, are increasing. The risk of dementia has been suggested to decrease with an increase in the intake of milk and dairy products. Therefore, the present study investigated the effects of consuming test food containing lactononadecapeptide (LNDP) on memory and attention in healthy elderly Japanese subjects aged 65 years or older over 24 weeks. A placebo-controlled, double-blind, randomized trial was conducted, and memory function was evaluated using the Rey-Osterrieth Complex Figure (ROCF) test and the total score of the Symbol Digit Modalities Test (SDMT). Based on the results of the ROCF test and SDMT, the repeated intake of the test food significantly improved memory function in elderly subjects. Therefore, the repeated intake of test food containing LNDP may improve memory and attention in elderly Japanese individuals with mild cognitive decline.
Keywords: Milk-derived peptides; Dementia; Memory function; Attention deficit
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