Synthetic Biology–Driven Innovation in the Production of Cosmetic Ingredients: From Natural Mimicry to Precision Creation

ABSTRACT: The cosmetics industry is undergoing a historic transition from natural extraction to precision biomanufacturing. Amino acid derivatives, as a kind of core functional cosmetic ingredient, have witnessed synthetic biology–based production technologies overcome traditional bottlenecks in efficiency and cost. In this Perspective, grounded in recent advances in the construction of amino acid derivative cell factories, we propose the core trends for the future development of cosmetic ingredients: enzyme engineering, dynamic metabolic control, and irrational strategies are converging to enable both functional customization and production intelligence. Star molecules such as ergothioneine, spermidine, and bioactive peptides are poised to redefine the boundaries of anti-aging efficacy, while AI-driven R&D paradigms offer broad prospects but must still overcome cost, regulatory, and consumer perception barriers. We emphasize that only by establishing an integrated “efficient synthesis–precise delivery–validated activity” end-to-end chain can cosmetic ingredients move from laboratory to market, achieving an industrial leap from chemical addition to biological empowerment.