In this article, we provided an overview of the current state of the SynBio industry in China with a focus on its research and technology, its main applications, and major players. We also discussed future prospects including the challenges and advantages of the SynBio industry in China.
Singh, AH, Kaufmann-Malaga BB, Lerman JA, Dougherty DP, Zhang Y, Kilbo AL, et al. An Automated Scientist to Design and Optimize Microbial Strains for the Industrial Production of Small Molecules. bioRxiv 2023, doi:10.1101/2023.01.03.521657.
Liu L, Wu L, Ma J, Wu X. Analysis of the deposits and samples of global patent microorganisms in the past 20 years. Acta Microbiol. Sin. 2021, 61, 3836–3843. [Google Scholar]
12.
Li SY, Zhao GP, Wang J. C-Brick: a new standard for assembly of biological parts using Cpf1. ACS Synth. Biol. 2016, 5, 1383–1388. [Google Scholar]
Liu Y, Cao Z, Wang Y, Guo Y, Xu P, Yuan P, et al. Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites. Nat. Biotech. 2018, 36, 1203–1210. [Google Scholar]
19.
Hu Y, Zu C, Zhang M, Wei G, Li W, Fu S, et al. Safety and efficacy of CRISPR-based non-viral PD1 locus specifically integrated anti-CD19 CAR-T cells in patients with relapsed or refractory Non-Hodgkin’s lymphoma: a first-in-human phase I study. Blood 2022, 144, 7491–7429. [Google Scholar]
20.
Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, et al. Transcriptional regulation of the Warburg effect in cancer by SIX1. Cancer Cell 2018, 33, 368–385. [Google Scholar]
CYZONE Research Report on the Development of China’s Synthetic Biology Industry in 2022. Available online: https://www.cyzone.cn/article/714214.html (accessed on 12 September 2023).
Figure 1.
Distribution of representative SynBio researcsh institutions in China, compiled based on publicly available data (Credit: Shenzhen Industrial Innovation Center for Engineering Biology).
Figure 2.
Distribution of representative SynBio companies in China by sector, compiled based on publicly available data (Credit: Shenzhen Industrial Innovation Center for Engineering Biology).