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Dynamic Metabolic Control: From the Perspective of Regulation Logic

Synthetic Biology and Engineering. 2023, 1(2), 10012; https://doi.org/10.35534/sbe.2023.10012
Tian Jiang    Chenyi Li    Yuxi Teng    Jianli Zhang    Diana Alexis Logan    Yajun Yan *   
School of Chemical, Materials, and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA 30602, USA
*
Authors to whom correspondence should be addressed.

Received: 20 Jun 2023    Accepted: 07 Aug 2023    Published: 28 Aug 2023   

(This article belongs to the Topic Collection Synthetic Biology in the Manufacturing of Chemicals and Fuels)
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Abstract

Establishing microbial cell factories has become a sustainable and increasingly promising approach for the synthesis of valuable chemicals. However, introducing heterologous pathways into these cell factories can disrupt the endogenous cellular metabolism, leading to suboptimal production performance. To address this challenge, dynamic pathway regulation has been developed and proven effective in improving microbial biosynthesis. In this review, we summarized typical dynamic regulation strategies based on their control logic. The applicable scenarios for each control logic were highlighted and perspectives for future research direction in this area were discussed.

Keywords

Dynamic regulation; Control logic; Feedback control; Oscillation

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