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Lactononadecapeptide Upregulates Gene Expression of Neuroplasticity and Cholinergic Activation in Human iPSC-Derived Neurons

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Lactononadecapeptide Upregulates Gene Expression of Neuroplasticity and Cholinergic Activation in Human iPSC-Derived Neurons

Junko Kimura 1,† Asako Kusumi 2 Koki Sato 3 Fumiya Nakamura 2 Kazuhito Ohsawa 2 Yoshihisa Kato 1 Shizuo Yamada 1,*

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1
Center for Pharma-Food Research (CPFR), Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
2
Core Technology Laboratories, Asahi Quality & Innovations, Ltd., 1-1-21 Midori, Moriya 302-0106, Japan
3
Technology Research & Development I, Research & Development Headquarters, Asahi Group Ltd., 1-1-21 Midori, Moriya 302-0106, Japan
*
Authors to whom correspondence should be addressed.
†
Present address: ItoCurio, 4-15-20 Ikarumi, Fujieda, Shizuoka 426-0015, Japan.

Received: 27 March 2026 Revised: 20 May 2026 Accepted: 25 June 2026 Published: 30 June 2026

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© 2026 The authors. This is an open access article under the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

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Food Res. Suppl. 2026, 1(2), 10009; DOI: 10.70322/frs.2026.10009
ABSTRACT: To clarify the underlying molecular mechanisms of lactononadecapeptide (LNDP), we examined its effects on the gene expression of memory-related neuroplasticity and cholinergic signaling in human induced pluripotent stem cell (hiPSC)-derived neurons, alongside a safety evaluation using PC12 cells. LNDP showed no cytotoxicity and significantly upregulated the expression of genes crucial for neuroplasticity (BDNF, TrkB, NGF) and cholinergic signaling (ChAT, CHRM1, NMDAR NR1) in hiPSC-derived neurons. These findings suggest that LNDP potentially modulates transcriptional pathways related to neural health, supporting its potential value as a functional food ingredient for cognitive decline.
Keywords: Lactononadecapeptide; Human iPSC-derived neurons; Memory; Gene expression

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