Origin, Anthropology and Genetic Relatedness of Amerindians

Deadline for manuscript submissions: 28 November 2025.

Guest Editor (1)

Antonio  Arnaiz-Villena
Prof. Antonio Arnaiz-Villena 
Department of Immunology, University Complutense of Madrid, Madrid, Spain<br />
Interests: Ornithology; HLA; Genetics; MHC; Anthropology; Histocompatibility; DNA Sequencing; Linguistics; Archaeology<br />

Special Issue Information

All First American Inhabitants are included in the Amerindians concept: the linguistic distinction with Canadian and Alaska Athabascan and southern USA Navajo and Apache as a Na Dene separated group is doubtful as well as Aleutians Islanders of Behring Strait. Mesoamericans and South American groups are also included and the most ancient human activities in America, have been detected in either California or South America (Brazil and Chile).
The Greenberg theory of America being an empty continent which was populated by three waves of people has been discarded because of facts have contracted it. The population of America was as ancient as it was in the rest of the World.
In the present issue, we aim to uncover some of the intriguing issues that have been put forward in the last years research. It covers all Amerindian anthropology topics, like origins, relatedness to other World populations and genetics. This latter issue is particularly interesting because some genetic markers isolate Amerindians from the rest of the Word, like HLA genes. It is most useful to concentrate in polymorphic markers like Y Chr, HLA and mtDNA since they more easily distinguish or separate population, in contrast to the also useful SNPs and STRs. However, whole genome use for population genetics may sometimes be useful but noise of non polymorphic sites usually obscure results and interpretantion in population genetics studies.
Linguistics, Genetics and all other Anthropology issues research on Amerindians are a wide range of topics that are intended to be included in this special issue in order to shed light on Amerndians origins and relatedness.

Published Papers (1 Papers)

Open Access

Review

29 October 2025

Admixture of Amerindian, African and European Genes: Cuba, Mexico and Colombia as Study Cases

One hundred years after Columbus arrived in America in 1492, Amerindian population had fallen from 80 to 8 million in North and South America. The main causes were new microbes, slavery conditions and war. The people of San Basilio de Palenque (Colombia), close to Cartagena, in the Colombian Caribbean Coast, were established by runaway African slaves who built a refuge in San Basilio. The Spanish governors pressured the Spanish monarchs in Madrid to grant freedom to the Africans of San Basilio de Palenque, who became the first free Africans in the Americas. They speak the only Bantu-Spanish Creole and preserve African genetic traits according to HLA genes. Research also examined Cubans from Havana, showing that around 12% of the typical Amerindian HLA genes are present in Havana’s population. Cubans’ blood contains Amerindian genes in spite of that Amerindian physical traits do not exist now in the Cuban population. Amerindian HLA and other genes analyses and other cultural traits observed in Mexico—such as those of the Pacific Mayo/Yoreme and the Atlantic Huastecan/Teenek groups—suggest that the initial peopling of the American continent occurred much earlier than traditionally proposed, and that there was a bidirectional exchange of populations between the Pacific and Atlantic in relation to Europe (finding in America of European Paleolothic Solutrean traits) peoples may have occurred.

Antonio Arnaiz-Villena*
Ignacio Juarez Martin-Delgado
Christian Vaquero-Yuste
Jose Manuel Martin-Villa
Tomas Lledo
Nat. Anthropol.
2025,
3
(4), 10018; 
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