Found 421 results
Open Access
Article
04 November 2024Exploring the Potential Relationship between Gut Microbiome Metabolites and Idiopathic Pulmonary Fibrosis via Network Pharmacology Study
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease with a poor prognosis. Previous research has revealed that the gut microbiota is associated with human health and immunity, and it interacts with the lung through the “gut-lung axis”. This study explores the potential relationship between Gut Microbiome Metabolites and Idiopathic pulmonary fibrosis via Network Pharmacology Study. The metabolites from gut microbiota were retrieved from the gutMGene database, and gene targets for these metabolites were obtained from previous studies. Gene targets of IPF were obtained from public databases (DisGeNET, OMIM). Subsequently, following the identification of shared targets, IL6 was determined as the core target through protein-protein interaction analysis. Then, a microbiota-metabolite-target-signaling pathway network (MMTS) was constructed using Cytoscape 3.10, and targets with low expression in the lungs and intestines were deleted. The MMTS network revealed that three short-chain fatty acids—acetate, butyrate, propionate, and a flavonoid compound called equol—are IL6-related metabolites. Then, we performed a molecular docking test (MDT) using CB-Dock2 to validate the affinity between core targets and metabolites. MDT confirmed that equol produced by the conversion of isoflavones from Lactobacillus paracasei JS1 was more stable in binding to IL6 than the other three short-chain fatty acids, thereby affecting multiple signaling pathways and influencing the progression of IPF. Finally, we validated this hypothesis through in vitro cell culture experiments, further confirming the effect of Equol.
Open Access
Article
04 November 2024Understanding Rural Consumer Credit Demand: Insights from China’s Household Income and Asset Structures
China’s ongoing supply-side structural reforms and the government’s strategic focus on rural revitalization catalyze a significant transformation in rural landscapes. The steady rise in rural residents’ incomes and assets, along with gradual improvements in household quality of life, is unlocking significant potential for growth and upgrades in the rural consumer market.This evolution necessitates a more diversified and sophisticated approach to financial services that is more inclusive and widespread. Despite the challenges, such as an aging population and imperfect credit systems that have limited the quality and precision of rural financial services, the analysis of household income and asset structures is vital for understanding consumption patterns and enhancing the economic vitality of rural households. Our study, based on the 2019 China Household Finance Survey data of 11,386 households and employing the Heckman two-stage model, finds that the proportions of income components and financial assets, moving in opposite directions, significantly influence the amount of consumer credit demanded, while other asset types, such as real estate, show no significant effect. The examination of income and asset diversity through the Herfindahl-Hirschman Index (HHI) demonstrates varying impacts of income and asset structures on credit demand, depending on the concentration levels of income and assets. Additionally, our analysis of heterogeneity based on the age of the household head and geographic region highlights the diverse influences on the amount of consumer credit demand, underscoring the importance of tailoring financial products and policies to meet the specific needs of rural households. These findings shed light on these dynamics and inform financial service innovations that align with the needs of rural consumers, thereby supporting the broader objectives of rural economic development and the achievement of China’s rural revitalization strategies.
Open Access
Article
01 November 2024The Agricultural Land Use Changes in Metropolitan Areas: A Case Study in Italy
In recent decades, countries have experienced a widespread increase in population that has resulted in unorganized urban sprawl, problems with land use change and related threats to natural resources. On the other hand, this led to converting agricultural areas into urban spaces. This work aims to analyze land use changes in the metropolitan area of Rome, which has experienced significant urbanization in rural areas. In this context, the agricultural sector’s contribution to the economic growth of peri-urban areas in the metropolitan area of Rome was verified. After showing the extent of agricultural land consumption, an economic evaluation of land use was provided through the analysis of the evolution of urban and peri-urban agriculture in Rome. The analysis was performed using the Italian FADN data for 2008–2020 and a set of structural and economic–financial indicators. Furthermore, the study analyzes the relationship between farm performance and agricultural resources, farmer demographics, and farm size. The analysis reveals that farms are mainly specialized in arable land and herbivores and are conducted prevalently by men with a high school education level and aged between 40 and 65 years. The economic results also show a good performance; however, they are yearly differentiated. Only a few farms resort to other gainful activities to increase the income produced. Therefore, a greater diversification of agricultural activities is desirable. The research provides interesting insights to stakeholders on the public support that needs to be designed and implemented to favor the survival of farms in rural areas.
Open Access
Article
01 November 2024Alkaline Modified Coir and Unmodified Hemp Fiber Reinforced Epoxy Based Composite for Automotive Application
The growing demand for sustainable materials in the automotive industry has prompted research into natural fiber-reinforced composites. To reduce carbon footprints and enhance product sustainability, the sectors increasingly focus on renewable and biodegradable materials. Composites made from natural fibers, such as coir and hemp, offer a promising solution for creating lightweight, high-performance components with a reduced environmental impact.In this study, an experimental investigation was conducted to examine the impact of single and hybrid and treated and untreated fibers, on the properties of epoxy-based composites. Untreated hemp fiber with treated Coir fiber was used for the research. The composites were fabricated through the open mould hand lay-up technique. Samples were prepared by randomly dispersing the fibers in the epoxy matrix before pouring them into the respective moulds prepared according to ASTM standards. Tensile, impact, and hardness tests were conducted on the cured samples to determine their mechanical properties, while a scanning electron microscope was used to evaluate the fractured surface. Water absorption tendencies were also determined. The results showed that the sample denoted as 5CF wt.% had the best property combination with tensile strength (32.4 MPa), tensile modulus (11.9 GPa), flexural strength (167.0 MPa), and impact strength (46.8 kJ/mm2). It was discovered that hemp fiber-based composites were not enhanced properly due to lack of fiber surface modifications. Though optimum results were obtained from treated coir fiber-based single/distinct composite, untreated hemp fiber was discovered to aid some flexural modulus and hardness properties in the hybrid composite based on the best results obtained in its distinct-based composite. Therefore, untreated hemp fiber can be used in hybrid form with treated coir fiber where one of the fibers is scarce or when fiber surface medication is difficult to achieve. Thus, the results showed that 5CH-based composites are the most suitable composition for automotive components development where high-mechanical properties are essential.
Open Access
Article
01 November 2024Energy Consumption and Economic Growth: Evidence from Electricity and Petroleum in Eastern Africa Region
This study investigates the distinct impacts of electricity and petroleum consumption on economic growth in Eastern Africa. Using a Panel Autoregressive Distributed Lag Model and data for a period spanning 2000 to 2021, the study examines both the short-run and long-run effects of these energy sources on Gross Domestic Product. The findings reveal that petroleum consumption has a statistically significant and positive impact on GDP in both the short run and long run. In contrast, while electricity consumption shows a positive but statistically insignificant effect on GDP in the short run, it exhibits a negative and statistically significant impact in the long run. These results suggest that policymakers in Eastern Africa should prioritize sustainable petroleum management to maximize its economic benefits while mitigating potential environmental risks. While the negative coefficient of electricity implies a corrective response of the variables to long-run equilibrium in the face of short-term shocks. As a result, it is recommended that economic shocks caused by energy consumption be considered in terms of their relationship to economic growth, whether positive or negative in the long or short term, as decision makers need to address their impact and limit such shocks on economic growth.
Open Access
Book Review
31 October 2024The Shennong’s Herbal Canon for Health Management of Herbal Foods
The Shennong’s Herbal Canon lays the foundation for the basic theory of herbal combination in traditional Chinese medicine (TCM). However, after the Tang dynasty, the text of this book was nearly entirely lost, with only a short preface and a catalogue of 365 herbs remaining. In Interpretation of Shennong’s Herb Canon and Catalogue of Herbal Foods, molecular anthropologist Hui Li systematically elaborated on the philosophical basis and practical application by starting from the TCM perspective and integrating multi-disciplinary scientific evidence. This book provides scholars with numerous empirical and logically-based scientific hypotheses and offers insights for daily health maintenance.
Open Access
Article
29 October 2024Experimental Study on Cold Plasma Jet (CPJ) Assisted Micro-Milling of 30CrMnSiNi2A
As a typical high-performance alloy, the excellent mechanical properties and stringent processing requirements of 30CrMnSiNi2A high-strength steel pose great challenges to high-quality and efficient processing. Currently, researchers have proposed methods such as improving cutting tool performance, minimal quantity lubrication (MQL), and applying external energy field to assist processing. However, due to the unregulated material properties, the further improvement of surface quality is limited, and there are problems of phase change and thermal damage in laser processing. Cold plasma jet (CPJ) is rich in active particles and has a low macroscopic temperature. It can effectively regulate material properties without causing serious surface damage. Therefore, a new 30CrMnSiNi2A machining approach adopting CPJ is proposed to improve the cutting process. The mechanism of its action on material properties and cutting process is revealed based on single-grain diamond scratching tests and micro-milling tests. The results show that CPJ can promote material fracture and improve material removal efficiency. The material removal efficiency R at 400 mN is increased from 0.433 before treatment to 0.895. Under the optimal processing parameters (feed speed Vf = 800 μm/s, spindle speed n = 40,000 rpm, and milling depth ap = 5 μm), compared with dry micro-milling, the cutting forces Fz, Fx and Fy in CPJ-assisted micro-milling are reduced by 26.5%, 24.8% and 31.3%, respectively. The surface roughness Sa is reduced by 19.3%, and the phenomena of plastic flow and burr are suppressed. The CPJ-assisted machining process proposed in this paper can regulate the material properties to improve the cutting process without causing serious damage to the material, providing a new approach for achieving high-quality and efficient processing of 30CrMnSiNi2A.
Open Access
Article
29 October 2024Postmortem Blood Metal Levels: Establishing Updated Reference Ranges Using ICP-OES
Postmortem testing for metals is crucial in forensic toxicology to determine whether metal exposure contributed to an individual’s death. However, current reference ranges for metal concentrations, primarily based on living individuals, fail to account for postmortem physiological changes. This study addresses this gap by analyzing thelevels of zinc and iron postmortem blood levels over various postmortem intervals (PMI) using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). Fifty samples were analyzed, revealing a significant increase in metal concentrations over time, with zinc levels rising from 181 μg/dL to 24,935 μg/dL and iron levels from 155 μg/dL to 11,421 μg/dL across a 40-month PMI. These changes are attributed to the redistribution of metals from tissues into the bloodstream and decomposition processes. The study proposes postmortem-specific reference ranges, emphasizing the need for forensic pathologists and toxicologists to consider PMI in their assessments to avoid misinterpretation and inaccurate cause-of-death determinations. This research underscores the necessity of updating reference ranges for postmortem analysis, ultimately improving the accuracy of forensic toxicology reports and contributing to more reliable determinations of cause of death.
Open Access
Article
28 October 2024Challenges and Solutions: China’s Illegal Hunting Crime from the Perspective of Ecological Civilization Development
In recent years, the number of crimes involving illegal hunting in China’s judicial system has steadily increased, giving rise to numerous disputes. The root of these disputes lies in the fact that China’s Criminal Law lags in terms of animal protection legislation, failing to strike a balance between wildlife protection and human rights. This disconnection is particularly evident in the legislation and judicial practice regarding illegal hunting crimes and the value principles of ecological civilization strongly advocated by China. Moreover, China’s legal framework and judicial practices concerning illegal hunting crimes suffer from low thresholds for conviction and a lack of comprehensive investigations into the subjective intentions of offenders. Chinese legislators and judges should consider international experiences in combating illegal hunting crimes, elucidate the right to defend oneself against wildlife in certain dangerous situations, and thoroughly revise legal provisions, including the definition of illegal hunting and related judicial interpretations. Additionally, greater efforts should be made to disseminate public legal knowledge regarding illegal hunting crimes.
Open Access
Review
28 October 2024Acute Exacerbations of Interstitial Lung Disease: Evolving Perspectives on Diagnosis and Management
Interstitial lung diseases (ILDs) are a heterogeneous group of chronic lung diseases caused by several potential etiologies but for many, the cause of a given ILD remains unknown. Accurate epidemiologic data are hard to find because of varying definitions, overlapping characteristics once thought to be unique to specific diseases, and ongoing changes in how ILDs are diagnosed and managed. In addition, there are significant variations in prevalence among different geographic populations, likely reflecting a combination of genetic and environmental differences. Certain risk factors, including exposure to cigarette smoke or environmental toxicants (asbestos, silica, fracking, coal dust, and air pollution), genetic mutations, and single nucleotide polymorphisms, have all been associated with developing interstitial lung disease. Due to the availability of high-resolution computed tomography (CT) scans, earlier and broader recognition of subtle imaging changes, and an aging worldwide population, the incidence and prevalence of ILDs are increasing. While a given cause of particular interstitial lung disease may vary, patients often experience breathlessness and a non-productive cough due to impaired alveolar gas exchange. Patients with ILD are prone to the development of acute exacerbations, marked by acute or chronic respiratory failure because of an acute exacerbation of the underlying lung disease. In this review, we discuss the definition of an acute exacerbation and comment on what is known about the underlying pathophysiology in exacerbations of idiopathic pulmonary fibrosis and other ILDs. We also emphasize the similarities in the clinical presentation of the acute exacerbations regardless of the underlying ILD, highlight key prognostic features of the diagnosis, and underscore the importance of interdisciplinary management of acute interstitial lung disease exacerbations.
