SCIEPublish

Novel Therapeutic Targets of Endothelial Inflammation in Acute Lung Injury and Acute Respiratory Distress Syndrome

lssue 1, Volume 3
Download PDF
Cite This Article
Contents

Commentary Open Access

Novel Therapeutic Targets of Endothelial Inflammation in Acute Lung Injury and Acute Respiratory Distress Syndrome

Yunchao Su 1,2,3,4,*
Author Information
Other Information
1
Department of Pharmacology & Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA
2
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
3
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
4
Research Service, Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA
*
Authors to whom correspondence should be addressed.

Received: 13 December 2025 Accepted: 14 January 2026 Published: 06 February 2026

Creative Commons

© 2026 The authors. This is an open access article under the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

Views:7
Downloads:4
J. Respir. Biol. Transl. Med. 2026, 3(1), 10001; DOI: 10.70322/jrbtm.2026.10001
ABSTRACT: Lung microvascular endothelial inflammation and barrier dysfunction play critical roles in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Despite recent scientific advances, the mortality of ALI/ARDS is still extremely high because the molecular mechanisms involved in ALI/ARDS remain unclear. In a recent issue of the journal Advanced Science, Baoyinna and colleagues reported that deubiquitinase USP30 induces lung microvascular inflammation and endothelial barrier disruption through the S-adenosylmethionine (SAM) cycle, DNA methylation, and miR-30a-5p down-regulation in ALI/ARDS. Their findings provide a strong rationale for targeting microRNAs, S-adenosylmethionine, DNA methylation, and deubiquitinating enzymes as potential therapeutic strategies for the treatment of ALI/ARDS.
Keywords: Lung; Endothelium; Inflammation; Barrier function; Acute lung injury; Acute respiratory distress syndrome

Graphical Abstract

TOP