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The Cellular and Metabolic Bases of Organ Fibrosis: UNIA Workshop 2023 in Baeza, Spain

Fibrosis. 2024, 2(1), 10001; https://doi.org/10.35534/fibrosis.2024.10001
Santiago Lamas 1    Katalin Susztak 2    Fernando Rodríguez-Pascual 1 *   
1
Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas (C.S.I.C.), Universidad Autónoma de Madrid (U.A.M.), 28049 Madrid, Spain
2
Renal, Electrolyte, and Hypertension Division, Department of Medicine/Institute for Diabetes, Obesity and Metabolism/Department of Genetics; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
*
Authors to whom correspondence should be addressed.

Received: 30 Jan 2024    Accepted: 18 Feb 2024    Published: 20 Feb 2024   

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Abstract

Fibrosis is defined by scarring and tissue hardening caused by excess deposition of extracellular matrix components, mainly collagens. A fibrotic response can occur in any tissue of the body and is the final outcome of an unbalanced reaction to inflammation and wound healing induced by a variety of insults, including persistent infections, autoimmune reactions, allergic responses, chemical exposure, radiation, and tissue injury. The accumulation of extracellular matrix proteins replaces the living tissue and disrupts the architecture leading to organ malfunction. Fibrosis remains a major clinical and therapeutic challenge and has been estimated to account for 45% of deaths in the developed world. While major advances regarding mechanistic knowledge on the underlying cell biology alterations in fibrosis have helped to characterize the main phases and mediators involved, this knowledge has not yielded significant progress in treatment. Only recently, the metabolic features associated to fibrosis have begun to emerge. This information, likely representing only the tip of the iceberg, suggests that metabolic derangement is a key culprit in the pathophysiology of fibrogenesis. The Workshop on The Cellular and Metabolic Bases of Organ Fibrosis, International University of Andalusia, Baeza, Spain, October 8–11, 2023 aimed to discuss the current knowledge and novel perspectives on the mechanisms contributing to the development of fibrosis in different organs and tissues, with particular focus on new methodological developments in metabolomics and therapeutic strategies.

Keywords

Fibrosis; Fibroblast; Inflammation; Metabolism; Tissue repair

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© 2024 by the authors; licensee SCIEPublish, SCISCAN co. Ltd. This article is an open access article distributed under the CC BY license (https://creativecommons.org/licenses/by/4.0/).