SCIEPublish

Recent Applications of mRNA-Based Technology for Disease Therapy

lssue 3, Volume 4
Download PDF
Cite This Article
Contents

Review Open Access

Recent Applications of mRNA-Based Technology for Disease Therapy

Jun Zhao 1,2,† Xiang Wen 1,2,† Yang Su 1,2,† Qiang Huang 2,3 Wei Jiang 2 Haoyang Wang 2,4 Jia Zhang 2 Yuting Li 2,* Xiangsheng Liu 1,2,*

Author Information
Other Information
1
School of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China
2
Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou 310018, China
3
Department of Urology, The First Hospital of China Medical University, Institute of Urology, China Medical University, Shenyang 110001, China
4
College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China
*
Authors to whom correspondence should be addressed.
†
The authors contributed equally to this work.

Received: 28 May 2026 Revised: 18 August 2026 Accepted: 01 September 2026 Published: 15 September 2026

Creative Commons

© 2026 The authors. This is an open access article under the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

Views:82
Downloads:28
Synth. Biol. Eng. 2026, 4(3), 10014; DOI: 10.70322/sbe.2026.10014
ABSTRACT: The success of COVID-19 mRNA vaccines has established mRNA as a powerful therapeutic platform. Key advantages of mRNA drugs include transient expression, rapid scalability, and universal protein-encoding capability. This review focuses on the application of mRNA therapies across a broad spectrum of diseases, including cancer, infectious diseases, genetic disorders, autoimmune diseases, and cardiovascular conditions. It systematically summarizes the latest progress in mRNA drug development, covering three major therapeutic paradigms: mRNA vaccines, protein replacement therapy, and mRNA-based gene editing. Emerging approaches, such as artificial intelligence tools for mRNA therapeutic design and advanced delivery systems, are also discussed. By integrating foundational mechanisms, engineering strategies, and translational examples, this review provides a comprehensive overview of the current landscape and future directions of mRNA-based therapeutics.
Keywords: mRNA therapeutics; mRNA vaccines; Protein replacement therapy; Gene editing; Lipid nanoparticles
TOP