Deadline for manuscript submissions: 31 July 2026.
Guest Editor (1)
Dr. David Snipelisky
Robert and Suzanne Tomsich Department of Cardiology, Section of Heart Failure & Cardiac Transplant Medicine, Cleveland Clinic, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA
Heart failure and cardiac transplantation remain among the most biologically and technically challenging areas in cardiovascular medicine. Despite advances in surgical technique and device engineering, fundamental questions about myocardial injury and repair, alloimmune responses, organ preservation, and the interface between advanced devices and recipient biology continue to limit curative progress. Recent breakthroughs in molecular cardiology, high-resolution imaging, immunomodulatory biology, regenerative strategies, and computational modelling are opening new mechanistic avenues that demand consolidation and critical appraisal.
This special issue, Insights in Heart Failure and Transplantation, seeks to curate high-quality basic, translational, and mechanistic clinical research that advances understanding of disease biology and therapeutic innovation. We invite contributions that elucidate molecular and cellular drivers of heart failure, refine approaches to immune monitoring and tolerance induction, improve donor organ assessment and preservation, and accelerate regenerative or device-integrated therapeutic strategies.
We welcome original research articles, focused reviews, systematic reviews and meta-analyses, and case reports addressing topics such as pathophysiology and molecular biomarkers of heart failure, myocardial regeneration and cell-based therapies, immunology of transplantation and rejection surveillance technologies, organ preservation and viability assessment, ventricular assist device design and biocompatibility, advanced imaging and diagnostic modalities, and computational or AI-driven models that illuminate biological mechanisms or predict biological responses.