Review Open Access

New Trends on Photoswitchable Antibiotics: From Syntheses to Applications

Photocatalysis: Research and Potential. 2023, 1(1), 10007;
ESCOM, TIMR (Integrated Transformations of Renewable Matter), Centre de Recherche Royallieu, Université de Technologie de Compiègne, CS 60319, F-60203 Compiègne Cedex, France
CNRS, Biomechanics and Bioengineering, Centre de Recherche Royallieu, Université de Technologie de Compiègne, CS 60319, F-60203 Compiègne Cedex, France
Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE – Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, University of Lille, F-59000 Lille, France
Junia, Health and Environment, Laboratory of Sustainable Chemistry and Health, F-59000 Lille, France
Authors to whom correspondence should be addressed.

Received: 27 Jan 2023    Accepted: 07 Oct 2023    Published: 12 Oct 2023   


Antibiotics are excreted in the environment after being used to treat bacterial infections in human and animals. These residues are poorly eliminated by the actual wastewater treatment processes, affecting animal, human and environmental health. This has led to the emergence of antibiotic resistance in bacterial pathogens. To combat this problem, photopharmacology has emerged in the last decades. This approach, based on the coupling of a drug with a photochromic component, is a promising way to control antibiotic activity by light irradiation and consequently limit antibioresistance. Thus, this review summarizes the study on the effect of the irradiation light on the antimicrobial activity of coupling compounds.


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