An Anti-Aging Tissue-Made Cosme-Nutraceutical Product: Effectiveness and Safety by an In Vitro and In Vivo Study

ABSTRACT: The evolution of the skin Industry, together with the consumer’s dream to maintain a younger appearance for living longer, has pushed the industry to formulate and distribute science-oriented cosmetics and diet supplements. Consequently, the worldwide production and selling of cosmeceuticals (specialized Cosmetics) and nutraceuticals (specialized diet supplements) have been notably increased for the consumer request of the Beauty from Within also. Thus the increased studies, formulations, and consumer requests of products more effective and safe. At this purpose the paper reports some data of a new pro-aging formulation controlled in vitro by the use of aged keratinocytes and fibroblasts and in vivo by controlling the skin of 30 selected women aged between 58 and 67 years. The studies have involved the use of an innovative anti-aging/pro-aging cosmeceutical-formulation con eyes by a specialized tissue (carrier-tissue). This tissue, made by selected active ingredients embedded into a biodegradable tissue-vehicle (activated-tissue), has been compared to the same actives embedded into a normal emulsion. The active ingredients used as anti-aging skin-repairing agents have been Nicotinamide, Allantoin, and sodium ascorbyl phosphate enriched by the fish-Collagen-peptides, considered an ingredient useful to increase the product’s penetrability through the skin’s Stratum Corneum when applied on its surface. On the other hand, both the tissues might be used as nutraceuticals also, due to their water-solubility, effectiveness, and safety. The selected and positive results, obtained by both the in vitro by keratinocytes/fibroblasts cultures and in vivo by engineering methods, will be reported and discussed, trying to show the effectiveness and safety of the realized tissues and the innovative cosme-nutraceutical’formulation.