Blood and Genomics Discovery Open Access

ISSN: 3078-221X (Online)

3078-5081 (Print)

Blood and Genomics Discovery moves back to the society and is no longer collaborated with SCIEPublish since 2025. Articles published in this journal will be available through SCIEPublish and the digital archive will be maintained at SCIEPublish.

Articles (1) All Articles

Open Access

Communication

08 October 2024

Alterations of T Cell Subsets Associated with Sickle Cell Trait

Sickle cell trait (SCT) has been associated with alterations in various immune-related laboratory parameters including lower circulating lymphocyte counts. To further characterize the impact of SCT on the immune system, we performed flow cytometry of monocyte and lymphocyte immune cell subsets from peripheral blood mononuclear cells collected in a large, community-based cohort of SCT-positive (n = 68) and SCT-negative (n = 959) Black adults. SCT was significantly associated with lower proportions of CD8+ and CD4+ T cell subsets that include senescent-like markers of repeated immune system challenges. These immune alterations could have potential implications for the susceptibility of individuals with SCT to various infectious diseases.

Open Access

Communication

08 October 2024

Alterations of T Cell Subsets Associated with Sickle Cell Trait

Sickle cell trait (SCT) has been associated with alterations in various immune-related laboratory parameters including lower circulating lymphocyte counts. To further characterize the impact of SCT on the immune system, we performed flow cytometry of monocyte and lymphocyte immune cell subsets from peripheral blood mononuclear cells collected in a large, community-based cohort of SCT-positive (n = 68) and SCT-negative (n = 959) Black adults. SCT was significantly associated with lower proportions of CD8+ and CD4+ T cell subsets that include senescent-like markers of repeated immune system challenges. These immune alterations could have potential implications for the susceptibility of individuals with SCT to various infectious diseases.

Alexander P. Reiner
Laura M. Raffield
Lynette Ekunwe
Nels C. Olson
Paul L. Auer
Margaret F. Doyle
Blood Genomics
2025,
9
(1), 10001; 
Open Access

Communication

08 October 2024

Alterations of T Cell Subsets Associated with Sickle Cell Trait

Sickle cell trait (SCT) has been associated with alterations in various immune-related laboratory parameters including lower circulating lymphocyte counts. To further characterize the impact of SCT on the immune system, we performed flow cytometry of monocyte and lymphocyte immune cell subsets from peripheral blood mononuclear cells collected in a large, community-based cohort of SCT-positive (n = 68) and SCT-negative (n = 959) Black adults. SCT was significantly associated with lower proportions of CD8+ and CD4+ T cell subsets that include senescent-like markers of repeated immune system challenges. These immune alterations could have potential implications for the susceptibility of individuals with SCT to various infectious diseases.utf-8

Alexander P. Reiner
Laura M. Raffield
Lynette Ekunwe
Nels C. Olson
Paul L. Auer
Margaret F. Doyle
Blood Genomics
2025,
9
(1), 10001; 
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