The wheel hub is an important part of the automobile, and machining affects its service life and driving safety. With the increasing demand for wheel productivity and machining accuracy in the automotive transport sector, automotive wheel production lines are gradually replacing human production. However, the technical difficulties of conventional automotive wheel production lines include insufficient intelligence, low machining precision, and large use of cutting fluid. This paper aims to address these research constraints. The intelligent, sustainable manufacturing production line for automobile wheel hub is designed. First, the machining of automotive wheel hubs is analyzed, and the overall layout of the production line is designed. Next, the process equipment system including the fixture and the minimum quantity lubrication (MQL) system are designed. The fixture achieves self-positioning and clamping functions through a linkage mechanism and a crank–slider mechanism, respectively, and the reliability of the mechanism is analyzed. Finally, the trajectory planning of the robot with dual clamping stations is performed by RobotStodio. Results show the machining parameters for a machining a wheel hub with a diameter of 580 mm are rotational speed of 2500 rpm, cutting depth of 4 mm, feed rate of 0.5 mm/r, and minimum clamping force of 10881.75 N. The average time to move the wheel hub between the roller table and each machine tool is 27 s, a reduction of 6 s compared with the manual handling time. The MQL system effectively reduces the use of cutting fluid. This production line can provide a basis and reference for actual production by reasonably planning the wheel hub production line.