Early Experience Using Implanted Hemodynamic Monitor (CardioMEMs) for Hemodynamic Assessment during Exercise in Pediatric Patients with Fontan Circulation

Assessment of Fontan pressures during exercise has been previously challenging. We report our experience with 4 children, in whom implanted hemodynamic monitor was utilized to assess Fontan pressures during exercise. Data was used to modify treatment in one case. The device provided useful insight into exercise-related changes in Fontan patients.

An Architecture for Early Wildfire Detection and Spread Estimation Using Unmanned Aerial Vehicles, Base Stations, and Space Assets

This paper presents, an autonomous and scalable monitoring system for early detection and spread estimation of wildfires by leveraging low-cost UAVs, satellite data and ground sensors. An array of ground sensors, such as fixed towers equipped with infrared cameras and IoT sensors strategically placed in areas with a high probability of wildfire, will work in tandem with the space domain as well as the air domain to generate an accurate and comprehensive flow of information. This system-of-systems approach aims to take advantage of the key benefits across all systems while ensuring seamless cooperation. Having scalability and effectiveness in mind, the system is designed to work with low-cost COTS UAVs that leverage infrared and RGB sensors which will act as the primary situational awareness generator on demand. AI task allocation algorithms and swarming-oriented area coverage methods are at the heart of the system, effectively managing the aerial assets High-level mission planning takes place in the GCS, where information from all sensors is gathered and compiled into a user-understandable schema. In addition, the GCS issues warnings for events such as the detection of fire and hardware failures, live video feed and lower-level control of the swarm and IoT sensors when requested. By performing intelligent sensor fusion, this solution will offer unparalleled reaction times to wildfires while also being resilient and reconfigurable should any hardware failures arise by incorporating state of the art swarming capabilities.

Immune Discovery: A New Open-access Journal to Share Your High-quality Research in Immunology

Investigating and Analyzing the Impact of a Bidirectional Multiport Power Electronic Transformer Interface on the Power Quality and Stability of Interconnected Microgrids

This paper investigates the potential benefits of a bidirectional multi-port power electronic transformer (MPPET) to interface multiple microgrids with utility distribution networks in terms of power quality and stability. The main concept is based on the interaction between the utility grid, the connected microgrids, and the MPPET in controlling the disturbances that lead to grid instability and power quality issues. The proposed MPPET does not require any serious communication infrastructure for operation. In addition, the MPPET can respond to reverse power flow caused by excess power generation on the grid. Due to the intermittent nature of the renewable energy sources and the different stages involved in the design of the proposed MPPET, the system is liable to internal DC voltage fluctuation, causing grid instability; thus, an energy storage system (ESS) is incorporated to avert the challenges. The networks under investigation and the proposed MPPET are designed and simulated using MATLAB and Simulink software. The electrical isolation capability of the proposed bidirectional MPPET is verified through simulation. Several case studies have been carried out to evaluate the behavior of the system under different operating conditions and to check the feasibility of MPPET for power quality improvements. It was observed that the MPPET is proficient in regulating power quality issues, thus enhancing grid stability. It is also varied that the proposed MPPET prevents the escalation of the impact of faults or disturbances all over the grid. At the same time, it is verified that the proposed bidirectional energy storage systems enhance energy transfer between the utility grid and microgrids, which improves the system’s stability.

Initial Stages of Development of an Automated Measurement Technique on Incisors

Teeth are an important object of studies in many scientific disciplines and, among various study techniques, measurements have one of the most promising prospects for further improvements supported by progress in computer sciences, imaging and image processing. Our recent work on automated odontometric algorithms for premolars and molars has gradually come to develop similar methods for another group of teeth—incisors. Using 3D reconstructions of teeth obtained through micro-focus tomographic scanning, we propose landmarks, which correspond to main morphological features of incisors and enable their formal description. In this article we present an orientation and measurement technique, based on an interpretation of incisor morphology, as a system which is able to perform in a fully automated mode. Since the primary objective of the current paper is to introduce methodological improvements, data on measurements and their results are shown at the most basic level.

Advancing Green Infrastructure Solutions in Rural Regions: Economic Impacts and Capacity Challenges in Southwest Ontario, Canada

Green infrastructure (GI) is a growing topic in urban planning, asset management, and climate change adaptation. However, rural regions have been under-represented in the discourse. This paper explores the benefits and challenges associated with the implementation and management of GI through a regional study of rural communities in southwestern Ontario. Our focus concerns the inter-relationships between GI, economic resilience, and the development of rural places. Findings show rural communities benefit from GI initiatives like natural stormwater management, park naturalization, and natural heritage restoration, which provide low-cost municipal services, conserve agricultural soils, and contribute to the amenity appeal of rural places. Challenges surrounding awareness, organizational capacity, and environmental regulation have slowed the uptake of GI and led to inconsistencies across jurisdictions. A mix of supportive policies, funding of demonstration projects with economic monitoring, and training to build professional capacity will advance the use and efficacy of GI across rural regions.

Solid Waste Recycling in Textile Processing Industries: A Case Study of India’s Clothing Hubs

This study investigated the type and amount of solid waste generation from textile wet processing industries and analyzed the disposal and recycling strategies implemented for its utilization. The method involved industrial interactions with textile processing mills. Data was gathered based on a field survey of manufacturing units and their compliance management teams. The solid waste generated in textile processing stages against input raw materials and fuel sources was recorded. The challenges in recycling solid waste are identified and further scope for its valorization is suggested. The results indicate that significant solid waste produced during the wet processing of textiles arises from waste fabric cuttings, combustion of fuels used in processing stages, and sludge generated from the post-effluent treatment. Around 80% of solid waste generated during the wet processing of textiles can find applications in the construction industry. Effective management of solid waste and its potential applications in construction are elaborated in detail.

A Review on Design of Sustainable Advanced Materials by Using Artificial Intelligence

This paper gives a comprehensive review of scientific interests and current methodologies of artificial intelligence applied to advanced material design and discovery by taking into account multiple sustainable design criteria such as functionalities, costs, environmental impacts, and recyclability. The main research activities include predicting material properties, compositions, and structures with data mining, new material discovery, hybrid modeling approaches combining AI techniques and classical computational formulations based on physical and chemical laws, and multicriteria optimization of materials. Based on this review, a short analysis is provided on the perspectives of this research area in the future, aiming at creating an everything connected material life cycle with real-time traceability systems

A Novel Animal Model for Pulmonary Hypertension: Lung Endothelial-Specific Deletion of Egln1 in Mice

Pulmonary arterial hypertension (PAH) is a devastating disease characterized by high blood pressure in the pulmonary arteries, which can potentially lead to heart failure over time. Previously, our lab found that endothelia-specific knockout of Egln1, encoding prolyl 4-hydroxylase-2 (PHD2), induced spontaneous pulmonary hypertension (PH). Recently, we elucidated that Tmem100 is a lung-specific endothelial gene using Tmem100-CreERT2 mice. We hypothesize that lung endothelial-specific deletion of Egln1 could lead to the development of PH without affecting Egln1 gene expression in other organs. Tmem100-CreERT2 mice were crossed with Egln1^flox/flox mice to generate Egln1^f/f;Tmem100-CreERT2 (LiCKO) mice. Western blot and immunofluorescent staining were performed to verify the knockout efficacy of Egln1 in multiple organs of LiCKO mice. PH phenotypes, including hemodynamics, right heart size and function, pulmonary vascular remodeling, were evaluated by right heart catheterization and echocardiography measurements. Tamoxifen treatment induced Egln1 deletion in the lung endothelial cells (ECs) but not in other organs of adult LiCKO mice. LiCKO mice exhibited an increase in right ventricular systolic pressure (RVSP, ~35 mmHg) and right heart hypertrophy. Echocardiography measurements showed right heart hypertrophy, as well as cardiac and pulmonary arterial dysfunction. Pulmonary vascular remodeling, including increased pulmonary wall thickness and muscularization of distal pulmonary arterials, was enhanced in LiCKO mice compared to wild-type mice. Tmem100 promoter-mediated lung endothelial knockout of Egln1 in mice leads to development of spontaneous PH. LiCKO mice could serve as a novel mouse model for PH to study lung and other organ crosstalk.

Efficacy and Cytocompatibility of a Pressure Garment—Silicone Composite Dressing Material for Scar Healing

Pressure garment therapy (PGT) and silicone gel sheeting (SGS) predominate non-invasive interventions for burn injuries, but the market lacks a composite solution combining pressure garment fabric (PGF) and medical-grade silicone (e.g. Biopor®AB) for multi-therapeutic efficacy. To address this gap, a versatile composite dressing of PGF-Biopor®AB was developed. PGF-Biopor®AB incorporates dual PGF-SGS therapy, mechanotherapy, and active moisture management, to facilitate recovery of hypertrophic subsidiary structures. The PGF structure enables the application of PGT, while the Biopor®AB silicone characteristics enforce silicone gel therapy (SGT). The PGF-SGS efficacy optimization not only reduces tension but also facilitates water vapor and oxygen penetration, along with hydration of the stratum corneum. Mechanotherapy, involving tension-shielding and pressure redistribution, promotes the reorganization of the collagen-fiber network. For active moisture management, the incorporation of a microchannel structure with active nylon absorbency facilitates effective moisture control through water absorption, retention, and cellular pathways of transport. In this study, the microscale features in the structure were further investigated. Under ISO 10993-5 standard, an over 70% cell viability in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay containing the L929 cell line verified the enhanced cell growth and inhibited proliferation, endorsing the safe usage of PGF-Biopor®AB. Patient studies of one-month efficacy in both high and low-cell-density samples and an early scarless healed wound suggest that over 70% cell viability is sufficient for optimal scar therapeutics. The multifaceted scar repair roles are fulfilled by addressing persistent inflammation, insufficient oxygenation, low levels of perfusion, and scar-healing tension, hence realising the multi-therapeutic efficacy of the composite dressing.