Background. Medallic art is used to promote the subject matter which is important for the issuer. Also fighting arts and martial traditions are used here as icons in the coins and medals. Problem. What is the purpose of occasional coins, medals or badges relative to their contents or symbolism, the metal used or the volume of the release? Does an issuer aim at promotion or rather at recognition and at maintaining the uniqueness? Material and Method. The study uses a regression method, comparative analysis and literature review. Approximately one hundred examples are discussed. Statistical analyses took into account N = 64 of contemporary coins (47) and medals (17), representing the relevant thematic groups. Pearson C coefficient was calculated for the factor of popularity FA and a number of variables. Results. It has been found that medals are issued in small volumes and are significantly varied in terms of the subject matter (uniqueness and originality). Some organisations seek to ensure the exceptional status of medal-type award which is granted based on strictly defined rules. Conclusions. Presentations of martial arts on coins, medals and badges make reference to the related symbolism or to the issuer’s national traditions. Large volume releases are mainly done for promotional purposes. On the other hand medals issued in small numbers are meant to be unique—they find their way to a select group of people deserving special recognition.
This research paper explores the financial adoption challenges of the Industrial Internet of Things (IIoT) in industry. Previous studies have mainly concentrated on designing affordable IIoT devices, reducing operational costs, and creating conceptual frameworks to assess the financial impact of IIoT adoption. The objective of this paper is to investigate whether IIoT adoption’s financial benefits outweigh the initial costs in small and medium-sized enterprises (SMEs). The data from the Industrial Assessment Centers (IAC) database were analyzed, focusing on 62 U.S. manufacturing SMEs across 10 states and 25 Standard Industrial Classifications (SICs), evaluating projected IIoT implementation costs and anticipated cost savings. Results from the analyses reveal that statistically, the difference between implementation costs and savings is significant at a 95% confidence level. Practically, this indicates that SMEs, despite facing high initial costs, can expect these investments to be counterbalanced by substantial savings. From an engineering perspective, this finding raises awareness among SMEs that, beyond overcoming financial barriers, IIoT technologies serve as a strategic enhancement to operational efficiency and competitive positioning. This study acknowledges the limitations including reliance on estimated projections and a narrow industry focus. Future research should broaden the sample and explore the lifecycle costs of IIoT.
Evaluating progress in human development and well-being is imperative for policymakers to assess the impact of their policies. Traditional measurement methods focus mostly on economic growth and socio-economic objectives, often neglecting vital components of the natural environment, particularly the ecological determinants essential for the sustainability of human well-being. The tension between sustainability and development becomes apparent as the recognition of the dependence of human well-being on the natural environment and ecosystem services is crucial for safeguarding the environment for present and future generations. This highlights the necessity for indicators that capture the intricate relationship between human well-being and environmental changes while addressing the challenges posed by the tension between sustainable practices and traditional development models. This paper presents a literature review examining the domains, dimensions, and indicators related to the sustainability of human well-being regarding economic, social, and natural environments. Emphasizing the multidimensional nature, this paper highlights the drawbacks of relying solely on socioeconomic indicators for assessment. The review explores diverse concepts and methodologies proposed to evaluate the components and multidimensional factors influencing the sustainability of human well-being. Ultimately it offers a holistic understanding serving as a foundation for further research and policy development.
With the continuous improvement of living standards, the importance of educational choice becomes more and more prominent. Based on the data of China General Social Survey (CGSS), a simultaneous equation model of identity, secondary vocational education choice and investment return is constructed. On the basis of fully considering endogeneity and sample selection bias, this paper analyzes the influence of identity on secondary vocational education choice and investment return by means of instrumental variables and propensity score matching (PSM). It is found that class differentiation is the main factor affecting class identity. The more blurred class differentiation, the higher class identity. Class identity has a significant positive impact on identity. The higher class identity, the easier it is to form identity. Identity has a direct positive impact on personal investment return. The stronger the identity, the higher the investment return. At the same time, identity has a significant positive impact on the choice of secondary vocational education. The stronger the identity, the more inclined to choose secondary vocational education. Compared with individuals with junior high school education, individuals with secondary vocational education have a higher return on education investment. Therefore, identity can not only directly improve an individual’s return on investment, but also improve the possibility of an individual’s choice of secondary vocational education, thereby improving an individual’s return on education investment, and ultimately increasing an individual’s return on investment.
The Asthma Risk Gene, GSDMB, Promotes Mitochondrial DNA-induced ISGs Expression
Released mitochondrial DNA (mtDNA) in cells activates cGAS-STING pathway, which induces expression of interferon-stimulated genes (ISGs) and thereby promotes inflammation, as frequently seen in asthmatic airways. However, whether the genetic determinant, Gasdermin B (GSDMB), the most replicated asthma risk gene, regulates this pathway remains unknown. We set out to determine whether and how GSDMB regulates mtDNA-activated cGAS-STING pathway and subsequent ISGs induction in human airway epithelial cells. Using qPCR, ELISA, native polyacrylamide gel electrophoresis, co-immunoprecipitation and immunofluorescence assays, we evaluated the regulation of GSDMB on cGAS-STING pathway in both BEAS-2B cells and primary normal human bronchial epithelial cells (nHBEs). mtDNA was extracted in plasma samples from human asthmatics and the correlation between mtDNA levels and eosinophil counts was analyzed. GSDMB is significantly associated with RANTES expression in asthmatic nasal epithelial brushing samples from the Genes-environments and Admixture in Latino Americans (GALA) II study. Over-expression of GSDMB promotes DNA-induced IFN and ISGs expression in bronchial epithelial BEAS-2B cells and nHBEs. Conversely, knockout of GSDMB led to weakened induction of interferon (IFNs) and ISGs in BEAS-2B cells. Mechanistically, GSDMB interacts with the C-terminus of STING, promoting the translocalization of STING to Golgi, leading to the phosphorylation of IRF3 and induction of IFNs and ISGs. mtDNA copy number in serum from asthmatics was significantly correlated with blood eosinophil counts especially in male subjects. GSDMB promotes the activation of mtDNA and poly (dA:dT)-induced activation of cGAS-STING pathway in airway epithelial cells, leading to enhanced induction of ISGs.
Pleurotus ostreatus, an edible white-rot fungus of great commercial and nutritional value, grows by metabolizing mainly glucose and xylose, the two major sugars in lignocellulosic biomass. In this study, a comparative proteomic analysis of P. ostreatus grown in submerged fermentation on a medium with glucose, xylose and mixtures of them as carbon sources was conducted. In the same conditions, the metabolic response of the fungus was evaluated in the production of the main nutritional components of the fungus such as proteins, lipids, and intracellular and extracellular polysaccharides. The proteomic analysis revealed that glucose and xylose upregulate different clusters of proteins. Glucose mainly up-regulates macromolecule metabolic processes, translation and glycolysis whereas xylose up-regulates, small molecule metabolic processes and tricarboxylic acid cycle (TCA). The mixtures show mostly similarities with the proteome response to glucose, although there are differential responses depending on xylose concentration. The carbon source type found to affect the basic macromolecule metabolic processes, with amino acids biosynthesis to differentiate mostly. An analysis of the upregulated proteins through the STRING database revealed that xylose upregulates mostly proteins related to amino acid biosynthesis. Leucine, Valine and Isoleucine biosynthesis pathways were found to be the most triggered pathway. All the branched-chain amino acids (BCAAs)-related enzymes intensities were gradually increased when xylose concentration was increased in the growth medium. BCAAs play an important role in the human diet so the enhancement of BCAAs biosynthesis pathway for P. ostreatus could convert it to a very remarkable protein substitute in human diet. These findings provide new insights into the proteomic and metabolic response of the fungus to the major sugars of lignocellulosic biomass, which are not well understood until now.
This article explored aspects of the community sport policy process in rural New South Wales, Australia, focusing on the views of community sport club (CSC) officials relating to policy matters. Community sport represents a complicated policy arena, and rural communities face a level of disparity compared with better-resourced urban CSCs, particularly concerning policy implementation and advocacy issues. Officials at CSCs from ten different sports (n = 10) in a rural setting participated in semi-structured interviews to pinpoint themes common in the community sport policy process. Further, the research identified aspects of the connections that impact CSCs, including those with government and National Sporting Organisations (NSOs). To highlight the beliefs and attitudes of the CSC officials, the interviews had two key thematic foci—implementation and advocacy—and the findings highlighted sub-themes relating to the fundamental interests of CSCs. Overall, the research accentuated the hierarchical nature—a power imbalance—of sport policy processes, the potential for CSCs to have a bottom-up role in policy creation, and the consideration of a policy analysis and evaluation structure such as the Advocacy Coalition Framework. Finally, the outcome points to enthusiasm for strengthening community sport by giving CSCs a voice through localized advocacy.
In agriculture, medicine, and engineering, sudden fire outbreaks are prevalent. During such events, the ensuing fire spread is extensive and unpredictable, necessitating crucial data for effective response and control. To address this need, the current initiative focuses on utilizing an Unmanned Aerial Vehicle (UAV) with an Infrared (IR) sensor. This sensor detects and analyses temperature variations, accompanied by additional camera footage capturing thermal images to pinpoint the locations of the incidents precisely. The UAV’s programming is executed using Arduino-Nano and mission planner software, interfacing with the Pixhawk flight controller operating in a guided mode for autonomous navigation. The UAV configuration includes a radio module interfacing with Arduino-Nano, a flight controller, and remote-control functionality. The flight duration is approximately 10–15 min, contingent upon flight dynamics and environmental temperature. Throughout its airborne operation, the UAV transmits live telemetry and log feeds to the connected computer, displaying critical parameters such as altitude, temperature, battery status, vertical speed, and distance from the operator. The Pixhawk flight controller is specifically programmed to govern the UAV’s behavior, issuing warnings to the pilot in case of low voltage, prompting a timely landing to avert potential crashes. In case of in-flight instability or a crash, the mission planner can trace the UAV’s location, facilitating efficient recovery and minimizing costs and component availability losses. This integrated approach enhances situational awareness and mitigation strategies, offering a comprehensive solution for managing fire incidents in diverse fields.
This study seeks to conceptualize ‘Informational Sustainability’ by examining the dynamic relationship between Sustainable Development and the Information and Communication Technologies (ICT) Revolution through the exploration of two prominent urban theories—Lefebvre’s ‘Right to the City’ and Castells’ ‘Rise of the Network Society’—to underscore the importance of knowledge integration in the development of informed, sustainable communities. Conducting a cross-country comparison between developed and developing nations, the study underscores the critical role of informational transformation in enabling resource efficiency, knowledge sharing, innovation, and informed decision-making—key for achieving Sustainable Development Goals (SDGs), while also highlighting potential risks associated with resisting ICT adoption, including hindered growth, increased inequalities, and reduced social engagement and environmental stewardship. The core focus of this conceptual framework is to validate the precursor role of ICT in building sustainable cities and communities by identifying synergies in Sustainable Development, defining dimensions for effective ICT application within the dynamic interplay of global and local levels, and identifying implementation gaps and necessary presumptions for its effective use.
The structure of the drying section in papermaking process is complex and too compacted to install sensors. In order to monitor the parameters in dynamic and manage the process practically with virtual simulations instead of physical experiments, a digital twin-based process parameter visualization model is constructed in this study. Regarding to the possible missing data in the modeling framework, it is proposed to combine industrial data, and knowledge of mechanism with intelligent algorithms to fill in the missing parameters. Upon which, a digital twin-based data visualization model is established using CADSIM Plus simulation software. Both of the knowledge -based mechanism solution model and the random forest-based parametric prediction model perform well, and the predicted parameters can support the digital twin visualization model in CADSIM Plus. Visual modeling of surface condenser in the paper drying section was realized for example, and results show that the model is capable of monitoring the dynamic changes of parameters in real time, so as to support the optimization and decision making of papermaking process such as formation, drying, et al.