High-Temperature Catalytic Platform Powered by Thermophilic Microorganisms and Thermozymes

Thermophilic microorganisms, capable of thriving under high temperatures, are emerging as key platforms for next-generation industrial biotechnology (NGIB), driving innovations in lignin biorefining, bioplastics synthesis, biodiesel production, and environmental remediation. Enzymes derived from thermophilic microorganisms, thermozymes, exhibit remarkable stability and efficiency under extreme conditions, making them highly suitable for diverse industrial applications. This review highlights recent advances in leveraging thermophilic microorganisms and thermozymes for high-temperature catalysis, focusing on their economic and environmental benefits. It also emphasizes progress in high-throughput screening and artificial intelligence (AI), which have revolutionized the bioprospecting, engineering, and application potential of thermozymes. Challenges and potential solutions for industrial implementation of high-temperature catalytic platforms are also discussed, highlighting their transformative impact on sustainable biotechnology.