Review Open Access

Thermoanaerobacter Species: The Promising Candidates for Lignocellulosic Biofuel Production

Synthetic Biology and Engineering. 2023, 1(1), 10005;

Kaiqun Dai1,   Chunyun Qu2,3,   Hongxin Fu1,   Jufang Wang1,4,*   

School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China
College of Light Industry and Food Science, Guangdong Provincial Key Laboratory of Science and Technology of Lingnan Special Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China
Key Laboratory of Green Processing and Intelligent Manufacturing of Lingnan Specialty Food, Ministry of Agriculture, Guangzhou 510225, China
Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510006, China
Authors to whom correspondence should be addressed.

Received: 31 Jan 2023    Accepted: 09 Mar 2023    Published: 15 Mar 2023   


Thermoanaerobacter species, which have broad substrate range and high operating temperature, can directly utilize lignocellulosic materials for biofuels production. Compared with the mesophilic process, thermophilic process shows greater prospects in consolidated bioprocessing (CBP) due to its relatively higher efficiency of lignocellulose degradation and lower risk of microbial contamination. Additionally, thermophilic conditions can reduce cooling costs, and further facilitate downstream product recovery. This review comprehensively summarizes the advances of Thermoanaerobacter species in lignocellulosic biorefinery, including their performance on substrates utilization, and genetic modification or other strategies for enhanced biofuels production. Furthermore, bottlenecks of sugar co-fermentation, metabolic engineering, and bioprocessing are also discussed.


Thermoanaerobacter; Lignocellulose; Biofuel; Co-fermentation; Metabolic engineering; Bioprocessing

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© 2023 by the authors; licensee SCIEPublish, SCISCAN co. Ltd. This article is an open access article distributed under the CC BY license (